ID:USBP1_HUMAN DESCRIPTION: RecName: Full=Usher syndrome type-1C protein-binding protein 1; Short=USH1C-binding protein 1; AltName: Full=AIE-75-binding protein; AltName: Full=MCC-2; AltName: Full=Mutated in colon cancer protein 2; SUBUNIT: Interacts via its C-terminus with the first PDZ domain of USH1C. INTERACTION: O15155:BET1; NbExp=2; IntAct=EBI-739895, EBI-749204; Q8IYI6:EXOC8; NbExp=2; IntAct=EBI-739895, EBI-742102; Q9BVI4:NOC4L; NbExp=2; IntAct=EBI-739895, EBI-395927; Q9UJW9:SERTAD3; NbExp=4; IntAct=EBI-739895, EBI-748621; TISSUE SPECIFICITY: Highest level of expression in heart, and moderate to low expression in skeletal muscle, kidney, liver, small intestine, placenta and lung. SIMILARITY: Belongs to the MCC family. SEQUENCE CAUTION: Sequence=BAC11443.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF10506 - PDZ domain of MCC-2 bdg protein for Usher syndrome
ModBase Predicted Comparative 3D Structure on Q8N6Y0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK075162 - Homo sapiens cDNA FLJ90681 fis, clone PLACE1005815, weakly similar to COLORECTAL MUTANT CANCER PROTEIN. AK292031 - Homo sapiens cDNA FLJ78457 complete cds, highly similar to Homo sapiens Usher syndrome 1C binding protein 1 (USHBP1), mRNA. BC027910 - Homo sapiens Usher syndrome 1C binding protein 1, mRNA (cDNA clone MGC:34110 IMAGE:5207170), complete cds. JD232443 - Sequence 213467 from Patent EP1572962. JD233995 - Sequence 215019 from Patent EP1572962. JD502531 - Sequence 483555 from Patent EP1572962. AK300617 - Homo sapiens cDNA FLJ59431 complete cds, highly similar to Homo sapiens Usher syndrome 1C binding protein 1 (USHBP1), mRNA. AB026290 - Homo sapiens mRNA for AIEBP, complete cds. AB040046 - Homo sapiens mRNA for MCC2-68, complete cds. AK096028 - Homo sapiens cDNA FLJ38709 fis, clone KIDNE2002883. AK315239 - Homo sapiens cDNA, FLJ96241, highly similar to Homo sapiens AIE-75 binding protein protein (MCC2), mRNA. JD185667 - Sequence 166691 from Patent EP1572962. JD173281 - Sequence 154305 from Patent EP1572962. JD440500 - Sequence 421524 from Patent EP1572962. JD219059 - Sequence 200083 from Patent EP1572962.