Human Gene MEOX1 (uc002idz.3)
Description: Homo sapiens mesenchyme homeobox 1 (MEOX1), transcript variant 1, mRNA.
RefSeq Summary (NM_004527): This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
Position: hg19 chr17:41,717,758-41,738,931 Size: 21,174 Total Exon Count: 3 Strand: -
Coding Region
Position: hg19 chr17:41,719,278-41,738,902 Size: 19,625 Coding Exon Count: 3
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: MEOX1_HUMAN
DESCRIPTION: RecName: Full=Homeobox protein MOX-1; AltName: Full=Mesenchyme homeobox 1;
FUNCTION: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation (By similarity).SUBCELLULAR LOCATION: Nucleus (Potential).SIMILARITY: Contains 1 homeobox DNA-binding domain.
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): MEOX1
CDC HuGE Published Literature: MEOX1
Positive Disease Associations: Body Height
Related Studies: Body Height , , .
[PubMed 0 ]
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR017970 - Homeobox_CS
IPR020479 - Homeobox_metazoa
IPR001356 - Homeodomain
IPR009057 - Homeodomain-like
Pfam Domains: PF00046 - Homeobox domain
SCOP Domains: 46689 - Homeodomain-like
ModBase Predicted Comparative 3D Structure on P50221
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0071837 HMG box domain binding
Biological Process: GO:0001757 somite specification
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007275 multicellular organism development
GO:0008150 biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060218 hematopoietic stem cell differentiation
GO:0061053 somite development
GO:0061056 sclerotome development
Cellular Component: GO:0005634 nucleus
GO:0005737 cytoplasm
Descriptions from all associated GenBank mRNAs
U10492 - Human Mox1 protein (MOX1) mRNA, complete cds.U10493 - Human Mox1a protein (MOX1a) mRNA, complete cds.JD082572 - Sequence 63596 from Patent EP1572962.JD117810 - Sequence 98834 from Patent EP1572962.JD332657 - Sequence 313681 from Patent EP1572962.JD045577 - Sequence 26601 from Patent EP1572962.JD149756 - Sequence 130780 from Patent EP1572962.JD465594 - Sequence 446618 from Patent EP1572962.JD445789 - Sequence 426813 from Patent EP1572962.JD232493 - Sequence 213517 from Patent EP1572962.JD158437 - Sequence 139461 from Patent EP1572962.JD450182 - Sequence 431206 from Patent EP1572962.JD171819 - Sequence 152843 from Patent EP1572962.JD263835 - Sequence 244859 from Patent EP1572962.JD546038 - Sequence 527062 from Patent EP1572962.JD078552 - Sequence 59576 from Patent EP1572962.JD228882 - Sequence 209906 from Patent EP1572962.JD372152 - Sequence 353176 from Patent EP1572962.JD121335 - Sequence 102359 from Patent EP1572962.JD146288 - Sequence 127312 from Patent EP1572962.JD193461 - Sequence 174485 from Patent EP1572962.AK291139 - Homo sapiens cDNA FLJ77122 complete cds, highly similar to Homo sapiens mesenchyme homeo box 1 (MEOX1), transcript variant 1, mRNA.JD252140 - Sequence 233164 from Patent EP1572962.JD137473 - Sequence 118497 from Patent EP1572962.BC069474 - Homo sapiens mesenchyme homeobox 1, mRNA (cDNA clone MGC:96893 IMAGE:7262102), complete cds.BC069506 - Homo sapiens mesenchyme homeobox 1, mRNA (cDNA clone MGC:96905 IMAGE:7262114), complete cds.JD260775 - Sequence 241799 from Patent EP1572962.JD215332 - Sequence 196356 from Patent EP1572962.CU686836 - Synthetic construct Homo sapiens gateway clone IMAGE:100022563 5' read MEOX1 mRNA.KJ891606 - Synthetic construct Homo sapiens clone ccsbBroadEn_01000 MEOX1 gene, encodes complete protein.EU446636 - Synthetic construct Homo sapiens clone IMAGE:100070264; IMAGE:100011845; FLH257301.01L mesenchyme homeobox 1 (MEOX1) gene, encodes complete protein.AB527749 - Synthetic construct DNA, clone: pF1KB7947, Homo sapiens MEOX1 gene for mesenchyme homeobox 1, without stop codon, in Flexi system.JD038861 - Sequence 19885 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: MEOX1_HUMAN, MOX1, NM_004527, NP_001035091, P50221, Q15069UCSC ID: uc002idz.3RefSeq Accession: NM_004527
Protein: P50221
(aka MEOX1_HUMAN)
CCDS: CCDS11466.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_004527.3
exon count:
3 CDS single in 3' UTR:
no
RNA size:
2330
ORF size:
765 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
1730.00 frame shift in genome:
no
% Coverage:
99.31
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
170 # strange splices:
0
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Methods, Credits, and Use Restrictions
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