Human Gene MEOX1 (uc002idz.3)
  Description: Homo sapiens mesenchyme homeobox 1 (MEOX1), transcript variant 1, mRNA.
RefSeq Summary (NM_004527): This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr17:41,717,758-41,738,931 Size: 21,174 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr17:41,719,278-41,738,902 Size: 19,625 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:41,717,758-41,738,931)mRNA (may differ from genome)Protein (254 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCHPRDLynxMalacardsMGI
neXtProtOMIMPubMedTreefamUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MEOX1_HUMAN
DESCRIPTION: RecName: Full=Homeobox protein MOX-1; AltName: Full=Mesenchyme homeobox 1;
FUNCTION: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation (By similarity).
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Contains 1 homeobox DNA-binding domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): MEOX1
CDC HuGE Published Literature: MEOX1
Positive Disease Associations: Body Height
Related Studies:
  1. Body Height
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: MEOX1
Diseases sorted by gene-association score: klippel-feil syndrome 2* (1019), isolated klippel-feil syndrome* (350), klippel-feil syndrome (26), diaphanospondylodysostosis (10), van buchem disease (6)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.56 RPKM in Adipose - Subcutaneous
Total median expression: 133.68 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -4.8029-0.166 Picture PostScript Text
3' UTR -527.021520-0.347 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017970 - Homeobox_CS
IPR020479 - Homeobox_metazoa
IPR001356 - Homeodomain
IPR009057 - Homeodomain-like

Pfam Domains:
PF00046 - Homeobox domain

SCOP Domains:
46689 - Homeodomain-like

ModBase Predicted Comparative 3D Structure on P50221
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0071837 HMG box domain binding

Biological Process:
GO:0001757 somite specification
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007275 multicellular organism development
GO:0008150 biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060218 hematopoietic stem cell differentiation
GO:0061053 somite development
GO:0061056 sclerotome development

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  U10492 - Human Mox1 protein (MOX1) mRNA, complete cds.
U10493 - Human Mox1a protein (MOX1a) mRNA, complete cds.
JD082572 - Sequence 63596 from Patent EP1572962.
JD117810 - Sequence 98834 from Patent EP1572962.
JD332657 - Sequence 313681 from Patent EP1572962.
JD045577 - Sequence 26601 from Patent EP1572962.
JD149756 - Sequence 130780 from Patent EP1572962.
JD465594 - Sequence 446618 from Patent EP1572962.
JD445789 - Sequence 426813 from Patent EP1572962.
JD232493 - Sequence 213517 from Patent EP1572962.
JD158437 - Sequence 139461 from Patent EP1572962.
JD450182 - Sequence 431206 from Patent EP1572962.
JD171819 - Sequence 152843 from Patent EP1572962.
JD263835 - Sequence 244859 from Patent EP1572962.
JD546038 - Sequence 527062 from Patent EP1572962.
JD078552 - Sequence 59576 from Patent EP1572962.
JD228882 - Sequence 209906 from Patent EP1572962.
JD372152 - Sequence 353176 from Patent EP1572962.
JD121335 - Sequence 102359 from Patent EP1572962.
JD146288 - Sequence 127312 from Patent EP1572962.
JD193461 - Sequence 174485 from Patent EP1572962.
AK291139 - Homo sapiens cDNA FLJ77122 complete cds, highly similar to Homo sapiens mesenchyme homeo box 1 (MEOX1), transcript variant 1, mRNA.
JD252140 - Sequence 233164 from Patent EP1572962.
JD137473 - Sequence 118497 from Patent EP1572962.
BC069474 - Homo sapiens mesenchyme homeobox 1, mRNA (cDNA clone MGC:96893 IMAGE:7262102), complete cds.
BC069506 - Homo sapiens mesenchyme homeobox 1, mRNA (cDNA clone MGC:96905 IMAGE:7262114), complete cds.
JD260775 - Sequence 241799 from Patent EP1572962.
JD215332 - Sequence 196356 from Patent EP1572962.
CU686836 - Synthetic construct Homo sapiens gateway clone IMAGE:100022563 5' read MEOX1 mRNA.
KJ891606 - Synthetic construct Homo sapiens clone ccsbBroadEn_01000 MEOX1 gene, encodes complete protein.
EU446636 - Synthetic construct Homo sapiens clone IMAGE:100070264; IMAGE:100011845; FLH257301.01L mesenchyme homeobox 1 (MEOX1) gene, encodes complete protein.
AB527749 - Synthetic construct DNA, clone: pF1KB7947, Homo sapiens MEOX1 gene for mesenchyme homeobox 1, without stop codon, in Flexi system.
JD038861 - Sequence 19885 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: MEOX1_HUMAN, MOX1, NM_004527, NP_001035091, P50221, Q15069
UCSC ID: uc002idz.3
RefSeq Accession: NM_004527
Protein: P50221 (aka MEOX1_HUMAN)
CCDS: CCDS11466.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_004527.3
exon count: 3CDS single in 3' UTR: no RNA size: 2330
ORF size: 765CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1730.00frame shift in genome: no % Coverage: 99.31
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 170# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.