Human Gene METTL25 (uc001szq.3) Description and Page Index
  Description: Homo sapiens methyltransferase like 25 (METTL25), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr12:82,752,276-82,873,016 Size: 120,741 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg19 chr12:82,752,345-82,872,803 Size: 120,459 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr12:82,752,276-82,873,016)mRNA (may differ from genome)Protein (603 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Methyltransferase-like protein 25; EC=2.1.1.-;
FUNCTION: Putative methyltransferase (By similarity).
SEQUENCE CAUTION: Sequence=BAB15484.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.91 RPKM in Thyroid
Total median expression: 86.36 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -23.4069-0.339 Picture PostScript Text
3' UTR -24.74213-0.116 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR025714 - Methyltranfer_dom

Pfam Domains:
PF13679 - Methyltransferase domain

SCOP Domains:
53335 - S-adenosyl-L-methionine-dependent methyltransferases

ModBase Predicted Comparative 3D Structure on Q8N6Q8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
  Protein SequenceProtein Sequence  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008168 methyltransferase activity
GO:0016740 transferase activity

Biological Process:
GO:0032259 methylation

-  Descriptions from all associated GenBank mRNAs
  AK310231 - Homo sapiens cDNA, FLJ17273.
BC029120 - Homo sapiens chromosome 12 open reading frame 26, mRNA (cDNA clone MGC:34762 IMAGE:5189049), complete cds.
KJ899762 - Synthetic construct Homo sapiens clone ccsbBroadEn_09156 C12orf26 gene, encodes complete protein.
DQ591734 - Homo sapiens piRNA piR-58846, complete sequence.
AK026442 - Homo sapiens cDNA: FLJ22789 fis, clone KAIA2171.
CU688600 - Synthetic construct Homo sapiens gateway clone IMAGE:100019928 5' read C12orf26 mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: C12orf26, MET25_HUMAN, NM_032230, NP_115606, Q8N6Q8, Q9H5Y3
UCSC ID: uc001szq.3
RefSeq Accession: NM_032230
Protein: Q8N6Q8 (aka MET25_HUMAN)
CCDS: CCDS9024.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_032230.2
exon count: 12CDS single in 3' UTR: no RNA size: 2105
ORF size: 1812CDS single in intron: no Alignment % ID: 99.95
txCdsPredict score: 3622.00frame shift in genome: no % Coverage: 99.48
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.