Human Gene SHE (uc001ffb.3) Description and Page Index
  Description: Homo sapiens Src homology 2 domain containing E (SHE), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:154,451,954-154,474,526 Size: 22,573 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr1:154,456,625-154,474,502 Size: 17,878 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:154,451,954-154,474,526)mRNA (may differ from genome)Protein (495 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: SHE_HUMAN
DESCRIPTION: RecName: Full=SH2 domain-containing adapter protein E;
SIMILARITY: Contains 1 SH2 domain.

-  MalaCards Disease Associations
  MalaCards Gene Search: SHE
Diseases sorted by gene-association score: blepharoconjunctivitis (9), blepharitis (6), strongyloidiasis (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.18 RPKM in Testis
Total median expression: 145.57 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.3024-0.304 Picture PostScript Text
3' UTR -1570.264671-0.336 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000980 - SH2

Pfam Domains:
PF00017 - SH2 domain

SCOP Domains:
55550 - SH2 domain

ModBase Predicted Comparative 3D Structure on Q5VZ18
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding

Biological Process:
GO:0007165 signal transduction
GO:0009967 positive regulation of signal transduction


-  Descriptions from all associated GenBank mRNAs
  JD364472 - Sequence 345496 from Patent EP1572962.
AK131004 - Homo sapiens cDNA FLJ27494 fis, clone TST03877.
AK074067 - Homo sapiens mRNA for FLJ00138 protein.
CR936736 - Homo sapiens mRNA; cDNA DKFZp686E14106 (from clone DKFZp686E14106).
CR936667 - Homo sapiens mRNA; cDNA DKFZp451D1511 (from clone DKFZp451D1511).
JD508992 - Sequence 490016 from Patent EP1572962.
JD536004 - Sequence 517028 from Patent EP1572962.
JD552269 - Sequence 533293 from Patent EP1572962.
JD284941 - Sequence 265965 from Patent EP1572962.
JD323954 - Sequence 304978 from Patent EP1572962.
JD166929 - Sequence 147953 from Patent EP1572962.
JD449004 - Sequence 430028 from Patent EP1572962.
JD305247 - Sequence 286271 from Patent EP1572962.
JD093344 - Sequence 74368 from Patent EP1572962.
JD165114 - Sequence 146138 from Patent EP1572962.
JD347151 - Sequence 328175 from Patent EP1572962.
JD432355 - Sequence 413379 from Patent EP1572962.
JD330521 - Sequence 311545 from Patent EP1572962.
JD082610 - Sequence 63634 from Patent EP1572962.
JD522678 - Sequence 503702 from Patent EP1572962.
JD229700 - Sequence 210724 from Patent EP1572962.
JD554240 - Sequence 535264 from Patent EP1572962.
JD402227 - Sequence 383251 from Patent EP1572962.
JD521474 - Sequence 502498 from Patent EP1572962.
JD399027 - Sequence 380051 from Patent EP1572962.
JD191769 - Sequence 172793 from Patent EP1572962.
JD335983 - Sequence 317007 from Patent EP1572962.
JD077237 - Sequence 58261 from Patent EP1572962.
JD205910 - Sequence 186934 from Patent EP1572962.
JD341346 - Sequence 322370 from Patent EP1572962.
JD359143 - Sequence 340167 from Patent EP1572962.
JD244552 - Sequence 225576 from Patent EP1572962.
JD160016 - Sequence 141040 from Patent EP1572962.
JD267659 - Sequence 248683 from Patent EP1572962.
JD170853 - Sequence 151877 from Patent EP1572962.
JD532773 - Sequence 513797 from Patent EP1572962.
JD073196 - Sequence 54220 from Patent EP1572962.
JD377643 - Sequence 358667 from Patent EP1572962.
JD442743 - Sequence 423767 from Patent EP1572962.
JD257066 - Sequence 238090 from Patent EP1572962.
JD358207 - Sequence 339231 from Patent EP1572962.
JD481617 - Sequence 462641 from Patent EP1572962.
JD481618 - Sequence 462642 from Patent EP1572962.
JD279577 - Sequence 260601 from Patent EP1572962.
JD449452 - Sequence 430476 from Patent EP1572962.
AK126006 - Homo sapiens cDNA FLJ44018 fis, clone TESTI4026079.
JD251486 - Sequence 232510 from Patent EP1572962.
JD366847 - Sequence 347871 from Patent EP1572962.
JD318887 - Sequence 299911 from Patent EP1572962.
JD364621 - Sequence 345645 from Patent EP1572962.
JD451544 - Sequence 432568 from Patent EP1572962.
JD546640 - Sequence 527664 from Patent EP1572962.
JD052261 - Sequence 33285 from Patent EP1572962.
JD363618 - Sequence 344642 from Patent EP1572962.
JD090029 - Sequence 71053 from Patent EP1572962.
JD244107 - Sequence 225131 from Patent EP1572962.
JD553303 - Sequence 534327 from Patent EP1572962.
JD357323 - Sequence 338347 from Patent EP1572962.
JD183432 - Sequence 164456 from Patent EP1572962.
JD333597 - Sequence 314621 from Patent EP1572962.
JD309213 - Sequence 290237 from Patent EP1572962.
JD177523 - Sequence 158547 from Patent EP1572962.
JD447027 - Sequence 428051 from Patent EP1572962.
JD508889 - Sequence 489913 from Patent EP1572962.
JD225881 - Sequence 206905 from Patent EP1572962.
JD542161 - Sequence 523185 from Patent EP1572962.
JD100886 - Sequence 81910 from Patent EP1572962.
JD474034 - Sequence 455058 from Patent EP1572962.
JD088913 - Sequence 69937 from Patent EP1572962.
JD083199 - Sequence 64223 from Patent EP1572962.
JD160523 - Sequence 141547 from Patent EP1572962.
JD421559 - Sequence 402583 from Patent EP1572962.
JD452929 - Sequence 433953 from Patent EP1572962.
JD074907 - Sequence 55931 from Patent EP1572962.
JD238009 - Sequence 219033 from Patent EP1572962.
JD426604 - Sequence 407628 from Patent EP1572962.
JD543126 - Sequence 524150 from Patent EP1572962.
JD497798 - Sequence 478822 from Patent EP1572962.
JD142566 - Sequence 123590 from Patent EP1572962.
JD303169 - Sequence 284193 from Patent EP1572962.
JD556893 - Sequence 537917 from Patent EP1572962.
JD183158 - Sequence 164182 from Patent EP1572962.
JD357716 - Sequence 338740 from Patent EP1572962.
JD552116 - Sequence 533140 from Patent EP1572962.
JD233449 - Sequence 214473 from Patent EP1572962.
JD046574 - Sequence 27598 from Patent EP1572962.
JD223631 - Sequence 204655 from Patent EP1572962.
JD226800 - Sequence 207824 from Patent EP1572962.
JD088196 - Sequence 69220 from Patent EP1572962.
JD106913 - Sequence 87937 from Patent EP1572962.
JD415958 - Sequence 396982 from Patent EP1572962.
JD525474 - Sequence 506498 from Patent EP1572962.
JD080228 - Sequence 61252 from Patent EP1572962.
JD391739 - Sequence 372763 from Patent EP1572962.
JD128213 - Sequence 109237 from Patent EP1572962.
JD420366 - Sequence 401390 from Patent EP1572962.
JD364462 - Sequence 345486 from Patent EP1572962.
JD203876 - Sequence 184900 from Patent EP1572962.
JD344003 - Sequence 325027 from Patent EP1572962.
JD070008 - Sequence 51032 from Patent EP1572962.
JD122510 - Sequence 103534 from Patent EP1572962.
JD068985 - Sequence 50009 from Patent EP1572962.
JD426751 - Sequence 407775 from Patent EP1572962.
JD052486 - Sequence 33510 from Patent EP1572962.
JD463030 - Sequence 444054 from Patent EP1572962.
JD212913 - Sequence 193937 from Patent EP1572962.
JD542869 - Sequence 523893 from Patent EP1572962.
JD432412 - Sequence 413436 from Patent EP1572962.
JD262041 - Sequence 243065 from Patent EP1572962.
JD087038 - Sequence 68062 from Patent EP1572962.
JD212912 - Sequence 193936 from Patent EP1572962.
JD402901 - Sequence 383925 from Patent EP1572962.
JD437437 - Sequence 418461 from Patent EP1572962.
JD323404 - Sequence 304428 from Patent EP1572962.
JD217074 - Sequence 198098 from Patent EP1572962.
JD371109 - Sequence 352133 from Patent EP1572962.
JD287790 - Sequence 268814 from Patent EP1572962.
JD333613 - Sequence 314637 from Patent EP1572962.
BC143765 - Homo sapiens Src homology 2 domain containing E, mRNA (cDNA clone MGC:177296 IMAGE:9052279), complete cds.
BC117210 - Homo sapiens Src homology 2 domain containing E, mRNA (cDNA clone MGC:150819 IMAGE:40125761), complete cds.
JD334500 - Sequence 315524 from Patent EP1572962.
JD101262 - Sequence 82286 from Patent EP1572962.
JD353951 - Sequence 334975 from Patent EP1572962.
JD437439 - Sequence 418463 from Patent EP1572962.
JD469812 - Sequence 450836 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001010846, NP_001010846, Q5VZ18, Q8TEQ5, SHE_HUMAN
UCSC ID: uc001ffb.3
RefSeq Accession: NM_001010846
Protein: Q5VZ18 (aka SHE_HUMAN)
CCDS: CCDS30877.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001010846.2
exon count: 6CDS single in 3' UTR: no RNA size: 6186
ORF size: 1488CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2870.00frame shift in genome: no % Coverage: 99.95
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.