Human Gene TXLNB (uc021zfy.1) Description and Page Index
  Description: Homo sapiens taxilin beta (TXLNB), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr6:139,561,199-139,613,208 Size: 52,010 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr6:139,563,663-139,610,036 Size: 46,374 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:139,561,199-139,613,208)mRNA (may differ from genome)Protein (684 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: TXLNB_HUMAN
DESCRIPTION: RecName: Full=Beta-taxilin; AltName: Full=Muscle-derived protein 77; Short=hMDP77;
FUNCTION: Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic.
SUBUNIT: Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A. Has a preference for STX1A.
INTERACTION: P40222:TXLNA; NbExp=2; IntAct=EBI-6116822, EBI-359793;
TISSUE SPECIFICITY: Expressed in skeletal muscle.
SIMILARITY: Belongs to the taxilin family.
SEQUENCE CAUTION: Sequence=CAD38924.2; Type=Erroneous initiation; Sequence=CAD91140.1; Type=Erroneous initiation;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TXLNB
CDC HuGE Published Literature: TXLNB

-  MalaCards Disease Associations
  MalaCards Gene Search: TXLNB
Diseases sorted by gene-association score: myotonic disease (5), myotonic dystrophy 1 (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D001564 Benzo(a)pyrene
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • D000082 Acetaminophen
  • D018817 N-Methyl-3,4-methylenedioxyamphetamine
  • D014028 Tobacco Smoke Pollution

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 60.18 RPKM in Muscle - Skeletal
Total median expression: 126.67 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -25.40165-0.154 Picture PostScript Text
3' UTR -647.872464-0.263 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026183 - Taxilin_fam

Pfam Domains:
PF09728 - Myosin-like coiled-coil protein

ModBase Predicted Comparative 3D Structure on Q8N3L3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0019905 syntaxin binding

Cellular Component:
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AL832322 - Homo sapiens mRNA; cDNA DKFZp451A175 (from clone DKFZp451A175).
BX647633 - Homo sapiens mRNA; cDNA DKFZp451B226 (from clone DKFZp451B226).
AL831988 - Homo sapiens mRNA; cDNA DKFZp451G083 (from clone DKFZp451G083).
BX647477 - Homo sapiens mRNA; cDNA DKFZp451H216 (from clone DKFZp451H216).
AL834248 - Homo sapiens mRNA; cDNA DKFZp451F022 (from clone DKFZp451F022); complete cds.
BC115383 - Homo sapiens taxilin beta, mRNA (cDNA clone MGC:134825 IMAGE:40038091), complete cds.
BC115384 - Homo sapiens taxilin beta, mRNA (cDNA clone MGC:134826 IMAGE:40038098), complete cds.
AB085905 - Homo sapiens hMDP77 mRNA for muscle-derived protein 77, complete cds.
AK314725 - Homo sapiens cDNA, FLJ95585.
KJ900378 - Synthetic construct Homo sapiens clone ccsbBroadEn_09772 TXLNB gene, encodes complete protein.
AB527233 - Synthetic construct DNA, clone: pF1KE0307, Homo sapiens TXLNB gene for taxilin beta, without stop codon, in Flexi system.
AM392784 - Synthetic construct Homo sapiens clone IMAGE:100002192 for hypothetical protein (TXLNB gene).
AM393407 - Synthetic construct Homo sapiens clone IMAGE:100002163 for hypothetical protein (TXLNB gene).
AM393849 - Synthetic construct Homo sapiens clone IMAGE:100002191 for hypothetical protein (TXLNB gene).
AF111704 - Homo sapiens SLTP001 (LST001) mRNA, complete cds.
JD303557 - Sequence 284581 from Patent EP1572962.
JD328236 - Sequence 309260 from Patent EP1572962.
JD440068 - Sequence 421092 from Patent EP1572962.
JD507911 - Sequence 488935 from Patent EP1572962.
JD046959 - Sequence 27983 from Patent EP1572962.
AK056970 - Homo sapiens cDNA FLJ32408 fis, clone SKMUS2000467.
JD273729 - Sequence 254753 from Patent EP1572962.
JD358385 - Sequence 339409 from Patent EP1572962.
JD472782 - Sequence 453806 from Patent EP1572962.
JD436278 - Sequence 417302 from Patent EP1572962.
JD434292 - Sequence 415316 from Patent EP1572962.
JD305745 - Sequence 286769 from Patent EP1572962.
JD207812 - Sequence 188836 from Patent EP1572962.
JD304627 - Sequence 285651 from Patent EP1572962.
JD039743 - Sequence 20767 from Patent EP1572962.
JD445293 - Sequence 426317 from Patent EP1572962.
JD151408 - Sequence 132432 from Patent EP1572962.
JD311046 - Sequence 292070 from Patent EP1572962.
JD410160 - Sequence 391184 from Patent EP1572962.
JD259917 - Sequence 240941 from Patent EP1572962.
JD250269 - Sequence 231293 from Patent EP1572962.
JD551617 - Sequence 532641 from Patent EP1572962.
JD182410 - Sequence 163434 from Patent EP1572962.
JD507669 - Sequence 488693 from Patent EP1572962.
JD090959 - Sequence 71983 from Patent EP1572962.
JD050612 - Sequence 31636 from Patent EP1572962.
JD562993 - Sequence 544017 from Patent EP1572962.
JD076837 - Sequence 57861 from Patent EP1572962.
JD201204 - Sequence 182228 from Patent EP1572962.
JD099286 - Sequence 80310 from Patent EP1572962.
JD459830 - Sequence 440854 from Patent EP1572962.
JD120907 - Sequence 101931 from Patent EP1572962.
JD151397 - Sequence 132421 from Patent EP1572962.
JD297923 - Sequence 278947 from Patent EP1572962.
JD202474 - Sequence 183498 from Patent EP1572962.
JD265564 - Sequence 246588 from Patent EP1572962.
JD428476 - Sequence 409500 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C6orf198, MDP77, NM_153235, NP_694967, Q5VTF3, Q76L25, Q86T52, Q8N3L3, Q8N3S2, TXLNB_HUMAN
UCSC ID: uc021zfy.1
RefSeq Accession: NM_153235
Protein: Q8N3L3 (aka TXLNB_HUMAN)
CCDS: CCDS34545.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_153235.3
exon count: 10CDS single in 3' UTR: no RNA size: 4685
ORF size: 2055CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4262.00frame shift in genome: no % Coverage: 99.89
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.