Human Gene TMEM233 (uc010szd.1) Description and Page Index
  Description: Homo sapiens transmembrane protein 233 (TMEM233), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr12:120,031,264-120,079,363 Size: 48,100 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr12:120,031,654-120,078,510 Size: 46,857 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:120,031,264-120,079,363)mRNA (may differ from genome)Protein (109 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGIneXtProtOMIMPubMedStanford SOURCE
UniProtKB

-  Comments and Description Text from UniProtKB
  ID: TM233_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 233; AltName: Full=Dispanin subfamily B member 2; Short=DSPB2; AltName: Full=Interferon-induced transmembrane domain-containing protein D2;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the CD225/Dispanin family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TMEM233
CDC HuGE Published Literature: TMEM233
Positive Disease Associations: Behcet Syndrome , Coronary Artery Disease
Related Studies:
  1. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  2. Coronary Artery Disease
    , , . [PubMed 0]

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.66 RPKM in Muscle - Skeletal
Total median expression: 31.64 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -158.71390-0.407 Picture PostScript Text
3' UTR -250.73853-0.294 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007593 - Interferon-induced_TM_protein

Pfam Domains:
PF04505 - Interferon-induced transmembrane protein

ModBase Predicted Comparative 3D Structure on B4DJY2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0009607 response to biotic stimulus

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK296289 - Homo sapiens cDNA FLJ50018 complete cds.
LF206934 - JP 2014500723-A/14437: Polycomb-Associated Non-Coding RNAs.
LF359479 - JP 2014500723-A/166982: Polycomb-Associated Non-Coding RNAs.
MA442511 - JP 2018138019-A/14437: Polycomb-Associated Non-Coding RNAs.
MA595056 - JP 2018138019-A/166982: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DJY2, IFITMD2, NM_001136534, NP_001130006, TM233_HUMAN
UCSC ID: uc010szd.1
RefSeq Accession: NM_001136534
Protein: B4DJY2 (aka TM233_HUMAN)
CCDS: CCDS44995.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001136534.1
exon count: 3CDS single in 3' UTR: no RNA size: 1573
ORF size: 330CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 547.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.