Human Gene MURC (uc004bba.3) Description and Page Index
  Description: Homo sapiens muscle-related coiled-coil protein (MURC), mRNA.
RefSeq Summary (NM_001018116): This gene encodes a protein containing two coiled-coil regions. The encoded protein promotes Rho/ROCK (Rho-kinase) signaling in cardiac muscles cells, and may facilitate myofibrillar organization. [provided by RefSeq, Jun 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK300099.1, BC090888.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr9:103,340,336-103,350,173 Size: 9,838 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr9:103,340,426-103,348,733 Size: 8,308 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:103,340,336-103,350,173)mRNA (may differ from genome)Protein (364 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
HGNCHPRDLynxMGIneXtProtOMIM
PubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: MURC_HUMAN
DESCRIPTION: RecName: Full=Muscle-related coiled-coil protein; AltName: Full=Muscle-restricted coiled-coil protein;
FUNCTION: Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway.
SUBUNIT: Interacts with SDPR; this augments the transactivation of NPPA.
SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere (By similarity). Cytoplasm (By similarity). Note=In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm (By similarity).
SIMILARITY: Belongs to the PTRF/SDPR family.
SEQUENCE CAUTION: Sequence=AAH90888.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 28.73 RPKM in Muscle - Skeletal
Total median expression: 71.72 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -13.7090-0.152 Picture PostScript Text
3' UTR -438.141440-0.304 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026752 - Cavin_fam

Pfam Domains:
PF15237 - PTRF/SDPR family

ModBase Predicted Comparative 3D Structure on Q5BKX8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organism development
GO:0007517 muscle organ development
GO:0010468 regulation of gene expression
GO:0030154 cell differentiation
GO:0035023 regulation of Rho protein signal transduction
GO:0045944 positive regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0016020 membrane
GO:0030017 sarcomere
GO:0030018 Z disc
GO:0042383 sarcolemma


-  Descriptions from all associated GenBank mRNAs
  AK300099 - Homo sapiens cDNA FLJ58620 complete cds, weakly similar to Polymerase I and transcript release factor.
EU487253 - Homo sapiens muscle-restricted coiled-coil protein (MURC) mRNA, complete cds.
BC090888 - Homo sapiens muscle-related coiled-coil protein, mRNA (cDNA clone MGC:102980 IMAGE:30529833), complete cds.
KJ905087 - Synthetic construct Homo sapiens clone ccsbBroadEn_14481 MURC gene, encodes complete protein.
AK128238 - Homo sapiens cDNA FLJ46372 fis, clone TESTI4051952.
JD440952 - Sequence 421976 from Patent EP1572962.
JD364480 - Sequence 345504 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B1PRL3, B4DT88, MURC_HUMAN, NM_001018116, NP_001018126, Q5BKX8
UCSC ID: uc004bba.3
RefSeq Accession: NM_001018116
Protein: Q5BKX8 (aka MURC_HUMAN)
CCDS: CCDS35083.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001018116.1
exon count: 2CDS single in 3' UTR: no RNA size: 2640
ORF size: 1095CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2384.00frame shift in genome: no % Coverage: 99.43
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.