Human Gene MURC (uc004bba.3) Description and Page Index
Description: Homo sapiens muscle-related coiled-coil protein (MURC), mRNA. RefSeq Summary (NM_001018116): This gene encodes a protein containing two coiled-coil regions. The encoded protein promotes Rho/ROCK (Rho-kinase) signaling in cardiac muscles cells, and may facilitate myofibrillar organization. [provided by RefSeq, Jun 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK300099.1, BC090888.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr9:103,340,336-103,350,173 Size: 9,838 Total Exon Count: 2 Strand: + Coding Region Position: hg19 chr9:103,340,426-103,348,733 Size: 8,308 Coding Exon Count: 2
ID:MURC_HUMAN DESCRIPTION: RecName: Full=Muscle-related coiled-coil protein; AltName: Full=Muscle-restricted coiled-coil protein; FUNCTION: Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway. SUBUNIT: Interacts with SDPR; this augments the transactivation of NPPA. SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere (By similarity). Cytoplasm (By similarity). Note=In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm (By similarity). SIMILARITY: Belongs to the PTRF/SDPR family. SEQUENCE CAUTION: Sequence=AAH90888.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5BKX8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0007275 multicellular organism development GO:0007517 muscle organ development GO:0010468 regulation of gene expression GO:0030154 cell differentiation GO:0035023 regulation of Rho protein signal transduction GO:0045944 positive regulation of transcription from RNA polymerase II promoter