Human Gene ASB15 (uc003vkw.1) Description and Page Index
  Description: Homo sapiens ankyrin repeat and SOCS box containing 15 (ASB15), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr7:123,249,112-123,277,932 Size: 28,821 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr7:123,254,557-123,277,035 Size: 22,479 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr7:123,249,112-123,277,932)mRNA (may differ from genome)Protein (588 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
PubMedReactomeStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Ankyrin repeat and SOCS box protein 15; Short=ASB-15;
FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
PATHWAY: Protein modification; protein ubiquitination.
DOMAIN: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin- protein ligase complexes (By similarity).
SIMILARITY: Contains 9 ANK repeats.
SIMILARITY: Contains 1 SOCS box domain.

-  MalaCards Disease Associations
  MalaCards Gene Search: ASB15
Diseases sorted by gene-association score: retinitis pigmentosa 11 (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.13 RPKM in Heart - Left Ventricle
Total median expression: 16.32 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -3.8042-0.090 Picture PostScript Text
3' UTR -187.84897-0.209 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom
IPR001496 - SOCS_C

Pfam Domains:
PF00023 - Ankyrin repeat
PF07525 - SOCS box
PF12796 - Ankyrin repeats (3 copies)
PF13606 - Ankyrin repeat
PF13637 - Ankyrin repeats (many copies)
PF13857 - Ankyrin repeats (many copies)

SCOP Domains:
48403 - Ankyrin repeat

ModBase Predicted Comparative 3D Structure on Q8WXK1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Protein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004842 ubiquitin-protein transferase activity
GO:0031625 ubiquitin protein ligase binding

Biological Process:
GO:0016567 protein ubiquitination
GO:0035556 intracellular signal transduction
GO:0043687 post-translational protein modification

Cellular Component:
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

-  Descriptions from all associated GenBank mRNAs
  AK125360 - Homo sapiens cDNA FLJ43370 fis, clone NTONG2005277, weakly similar to ANKYRIN 1.
AF428257 - Homo sapiens hypothetical protein mRNA, complete cds.
BC100874 - Homo sapiens ankyrin repeat and SOCS box-containing 15, mRNA (cDNA clone IMAGE:40003168), partial cds.
BC100875 - Homo sapiens ankyrin repeat and SOCS box-containing 15, mRNA (cDNA clone IMAGE:40003169), partial cds.
BC100876 - Homo sapiens ankyrin repeat and SOCS box-containing 15, mRNA (cDNA clone IMAGE:40003172), partial cds.
BC100877 - Homo sapiens ankyrin repeat and SOCS box-containing 15, mRNA (cDNA clone IMAGE:40003175), partial cds.
BC166689 - Synthetic construct Homo sapiens clone IMAGE:100066415, MGC:195552 ankyrin repeat and SOCS box-containing 15 (ASB15) mRNA, encodes complete protein.
GQ900990 - Homo sapiens clone HEL-T-102 epididymis secretory sperm binding protein mRNA, complete cds.
CR749595 - Homo sapiens mRNA; cDNA DKFZp779M1258 (from clone DKFZp779M1258).
AF403033 - Homo sapiens ankyrin repeat domain-containing SOCS box protein Asb-15 mRNA, partial cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8WXK1 (Reactome details) participates in the following event(s):

R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex
R-HSA-983147 Release of E3 from polyubiquitinated substrate
R-HSA-8952039 NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex
R-HSA-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases
R-HSA-8952044 AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex
R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2
R-HSA-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
R-HSA-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-8951664 Neddylation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-597592 Post-translational protein modification
R-HSA-1280218 Adaptive Immune System
R-HSA-392499 Metabolism of proteins
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: ASB15_HUMAN, NM_080928, NP_563616, Q3ZCP3, Q3ZCP5, Q68D37, Q8WXK1
UCSC ID: uc003vkw.1
RefSeq Accession: NM_080928
Protein: Q8WXK1 (aka ASB15_HUMAN or AS15_HUMAN)
CCDS: CCDS34742.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_080928.3
exon count: 10CDS single in 3' UTR: no RNA size: 2706
ORF size: 1767CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3734.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.