Human Gene VGLL2 (uc003pxn.3) Description and Page Index
Description: Homo sapiens vestigial like 2 (Drosophila) (VGLL2), transcript variant 1, mRNA. RefSeq Summary (NM_182645): This gene encodes a protein with a transcriptional enhancer factor 1 (TEF-1) interaction domain. The encoded protein may act as a co-factor of TEF-1 regulated gene expression during skeletal muscle development. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]. Transcript (Including UTRs) Position: hg19 chr6:117,586,721-117,594,728 Size: 8,008 Total Exon Count: 4 Strand: + Coding Region Position: hg19 chr6:117,586,927-117,593,657 Size: 6,731 Coding Exon Count: 4
ID:VGLL2_HUMAN DESCRIPTION: RecName: Full=Transcription cofactor vestigial-like protein 2; Short=Vgl-2; AltName: Full=Protein VITO1; FUNCTION: May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles. SUBUNIT: Interacts with TEFs. Binds to TEAD1/TEF1. SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Skeletal muscle. SIMILARITY: Belongs to the vestigial family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N8G2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003713 transcription coactivator activity GO:0005515 protein binding GO:0008022 protein C-terminus binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0007519 skeletal muscle tissue development GO:0045944 positive regulation of transcription from RNA polymerase II promoter