Human Gene LRRC14B (uc003jal.1) Description and Page Index
  Description: Homo sapiens leucine rich repeat containing 14B (LRRC14B), mRNA.
RefSeq Summary (NM_001080478): The protein encoded by this gene is a leucine-rich repeat containing protein that is a member of the PRAME family. [provided by RefSeq, Apr 2017]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.126157.1, SRR3476690.867456.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000328278.4/ ENSP00000327675.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr5:191,626-195,468 Size: 3,843 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr5:191,654-195,468 Size: 3,815 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:191,626-195,468)mRNA (may differ from genome)Protein (514 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
HGNCHPRDLynxMGIneXtProtPubMed
Stanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: LR14B_HUMAN
DESCRIPTION: RecName: Full=Leucine-rich repeat-containing protein 14B;
SIMILARITY: Belongs to the PRAME family.
SIMILARITY: Contains 5 LRR (leucine-rich) repeats.
CAUTION: It is uncertain whether Met-1 or Met-4 is the initiator.

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.69 RPKM in Heart - Left Ventricle
Total median expression: 34.96 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -6.9028-0.246 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026292 - PRAME/Leu_rich_rep-con_p14

SCOP Domains:
52047 - RNI-like
52058 - L domain-like
52075 - Outer arm dynein light chain 1

ModBase Predicted Comparative 3D Structure on A6NHZ5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Descriptions from all associated GenBank mRNAs
  LF384937 - JP 2014500723-A/192440: Polycomb-Associated Non-Coding RNAs.
BC156515 - Synthetic construct Homo sapiens clone IMAGE:100063099, MGC:190690 leucine-rich repeat-containing protein 14-like (LOC389257) mRNA, encodes complete protein.
BC172511 - Synthetic construct Homo sapiens clone IMAGE:100069205, MGC:199216 leucine-rich repeat-containing protein 14-like (LOC389257) mRNA, encodes complete protein.
MA620514 - JP 2018138019-A/192440: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NHZ5, LR14B_HUMAN, NM_001080478, NP_001073947
UCSC ID: uc003jal.1
RefSeq Accession: NM_001080478
Protein: A6NHZ5 (aka LR14B_HUMAN)
CCDS: CCDS47184.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001080478.1
exon count: 2CDS single in 3' UTR: no RNA size: 1573
ORF size: 1545CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2459.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.