Human Gene C3orf43 (uc003fws.3) Description and Page Index
  Description: Homo sapiens chromosome 3 open reading frame 43 (C3orf43), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr3:196,233,750-196,242,237 Size: 8,488 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr3:196,234,758-196,242,080 Size: 7,323 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr3:196,233,750-196,242,237)mRNA (may differ from genome)Protein (214 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsGeneNetworkH-INV
HPRDLynxMGIneXtProtPubMedStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Uncharacterized protein C3orf43;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.18 RPKM in Heart - Left Ventricle
Total median expression: 31.45 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -39.44157-0.251 Picture PostScript Text
3' UTR -266.261008-0.264 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15080 - Domain of unknown function (DUF4547)

ModBase Predicted Comparative 3D Structure on Q147U7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  AL833140 - Homo sapiens mRNA; cDNA DKFZp313B0440 (from clone DKFZp313B0440).
AK123917 - Homo sapiens cDNA FLJ41923 fis, clone PERIC2003090.
AL833443 - Homo sapiens mRNA; cDNA DKFZp313J1442 (from clone DKFZp313J1442).
JD444212 - Sequence 425236 from Patent EP1572962.
JD381131 - Sequence 362155 from Patent EP1572962.
JD188876 - Sequence 169900 from Patent EP1572962.
AK291522 - Homo sapiens cDNA FLJ77313 complete cds.
BC118556 - Homo sapiens chromosome 3 open reading frame 43, mRNA (cDNA clone MGC:141735 IMAGE:40023903), complete cds.
BC118636 - Homo sapiens chromosome 3 open reading frame 43, mRNA (cDNA clone MGC:141734 IMAGE:40023902), complete cds.
KJ895916 - Synthetic construct Homo sapiens clone ccsbBroadEn_05310 C3orf43 gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KW20, CC043_HUMAN, NM_001077657, NP_001071125, Q147U7
UCSC ID: uc003fws.3
RefSeq Accession: NM_001077657
Protein: Q147U7 (aka CC043_HUMAN)
CCDS: CCDS43192.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001077657.1
exon count: 3CDS single in 3' UTR: no RNA size: 1810
ORF size: 645CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1484.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.