Human Gene CCDC141 (uc002une.2) Description and Page Index
  Description: Homo sapiens coiled-coil domain containing 141 (CCDC141), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr2:179,694,484-179,914,786 Size: 220,303 Total Exon Count: 24 Strand: -
Coding Region
   Position: hg19 chr2:179,698,900-179,914,668 Size: 215,769 Coding Exon Count: 24 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesGeneReviewsModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:179,694,484-179,914,786)mRNA (may differ from genome)Protein (1530 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIOMIM
PubMedStanford SOURCEUniProtKB

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CCDC141
CDC HuGE Published Literature: CCDC141
Positive Disease Associations: Triglycerides
Related Studies:
  1. Triglycerides
    , , . [PubMed 0]
  2. Triglycerides
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: CCDC141
Diseases sorted by gene-association score: kallmann syndrome (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.76 RPKM in Heart - Left Ventricle
Total median expression: 12.10 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -25.10118-0.213 Picture PostScript Text
3' UTR -1118.254416-0.253 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR013098 - Ig_I-set
IPR003598 - Ig_sub2
IPR018159 - Spectrin/alpha-actinin
IPR002017 - Spectrin_repeat

Pfam Domains:
PF00435 - Spectrin repeat
PF07679 - Immunoglobulin I-set domain
PF13927 - Immunoglobulin domain

SCOP Domains:
46966 - Spectrin repeat
48726 - Immunoglobulin

ModBase Predicted Comparative 3D Structure on H7C0P1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
      
      

-  Descriptions from all associated GenBank mRNAs
  BX649042 - Homo sapiens mRNA; cDNA DKFZp779P0262 (from clone DKFZp779P0262).
LP895416 - Sequence 280 from Patent EP3253886.
AK096821 - Homo sapiens cDNA FLJ39502 fis, clone PROST2017098.
AL832777 - Homo sapiens mRNA; cDNA DKFZp686G197 (from clone DKFZp686G197).
JD364982 - Sequence 346006 from Patent EP1572962.
JD040998 - Sequence 22022 from Patent EP1572962.
JD553728 - Sequence 534752 from Patent EP1572962.
JD295508 - Sequence 276532 from Patent EP1572962.
JD207183 - Sequence 188207 from Patent EP1572962.
JD316144 - Sequence 297168 from Patent EP1572962.
JD036989 - Sequence 18013 from Patent EP1572962.
JD379589 - Sequence 360613 from Patent EP1572962.
JD120507 - Sequence 101531 from Patent EP1572962.
JD096558 - Sequence 77582 from Patent EP1572962.
JD233854 - Sequence 214878 from Patent EP1572962.
JD251566 - Sequence 232590 from Patent EP1572962.
JD284231 - Sequence 265255 from Patent EP1572962.
JD244739 - Sequence 225763 from Patent EP1572962.
JD115387 - Sequence 96411 from Patent EP1572962.
JD398838 - Sequence 379862 from Patent EP1572962.
JD050195 - Sequence 31219 from Patent EP1572962.
JD503843 - Sequence 484867 from Patent EP1572962.
AK129847 - Homo sapiens cDNA FLJ26337 fis, clone HRT02844.
BC115378 - Homo sapiens coiled-coil domain containing 141, mRNA (cDNA clone MGC:134803 IMAGE:40028485), complete cds.
KJ904146 - Synthetic construct Homo sapiens clone ccsbBroadEn_13540 CCDC141 gene, encodes complete protein.
JD372744 - Sequence 353768 from Patent EP1572962.
JD236289 - Sequence 217313 from Patent EP1572962.
BC108697 - Homo sapiens coiled-coil domain containing 141, mRNA (cDNA clone IMAGE:4345701), partial cds.
BC087856 - Homo sapiens cDNA clone IMAGE:30376005.
JD421260 - Sequence 402284 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: FLJ39502, H7C0P1, H7C0P1_HUMAN, hCG_22663, NM_173648, NP_775919
UCSC ID: uc002une.2
RefSeq Accession: NM_173648
Protein: H7C0P1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene CCDC141:
kms (Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_173648.3
exon count: 24CDS single in 3' UTR: no RNA size: 9127
ORF size: 4593CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 7823.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.