Human Gene SDK1 (uc003smx.3) Description and Page Index
Description: Homo sapiens sidekick cell adhesion molecule 1 (SDK1), transcript variant 1, mRNA. RefSeq Summary (NM_152744): The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains six immunoglobulin-like domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]. Transcript (Including UTRs) Position: hg19 chr7:3,341,080-4,308,631 Size: 967,552 Total Exon Count: 45 Strand: + Coding Region Position: hg19 chr7:3,341,219-4,305,016 Size: 963,798 Coding Exon Count: 45
ID:SDK1_HUMAN DESCRIPTION: RecName: Full=Protein sidekick-1; Flags: Precursor; FUNCTION: Cell adhesion protein that guides axonal terminals to specific synapses in developing neurons. Dysregulation of this protein may play an important role in podocyte dysfunction in HIV- associated nephropathy. SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential). TISSUE SPECIFICITY: Up-regulated in glomeruli in HIV-associated nephropathy. In diseased glomeruli, significantly overexpressed and the expression is no longer restricted to mesangial cells but includes podocytes and parietal epithelial cells. SIMILARITY: Contains 13 fibronectin type-III domains. SIMILARITY: Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
Genetic Association Studies of Complex Diseases and Disorders
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 48726 - Immunoglobulin 49265 - Fibronectin type III
ModBase Predicted Comparative 3D Structure on Q7Z5N4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.