Human Gene RNF180 (uc003jti.3) Description and Page Index
Description: Homo sapiens ring finger protein 180 (RNF180), transcript variant 1, mRNA.
Transcript (Including UTRs)
Position: hg19 chr5:63,461,671-63,668,696 Size: 207,026 Total Exon Count: 8 Strand: +
Position: hg19 chr5:63,496,635-63,665,641 Size: 169,007 Coding Exon Count: 7
Data last updated: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase RNF180; EC=6.3.2.-; AltName: Full=RING finger protein 180;
FUNCTION: E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2 (By similarity). PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with ZIC2 (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus envelope (By similarity). DOMAIN: The RING-type zinc finger domain mediates polyubiquitination of the interacting protein. SIMILARITY: Contains 1 RING-type zinc finger. SEQUENCE CAUTION: Sequence=CAD89939.1; Type=Erroneous initiation;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive):
RNF180 CDC HuGE Published Literature:
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
Press "+" in the title bar above to open this section.
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
Press "+" in the title bar above to open this section.
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR001841 - Znf_RING
IPR013083 - Znf_RING/FYVE/PHD
IPR017907 - Znf_RING_CS
Pfam Domains: PF00097 - Zinc finger, C3HC4 type (RING finger)
PF13445 - RING-type zinc-finger
PF13920 - Zinc finger, C3HC4 type (RING finger)
SCOP Domains: 57850 - RING/U-box
57903 - FYVE/PHD zinc finger
ModBase Predicted Comparative 3D Structure on Q86T96
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AL832580 - Homo sapiens mRNA; cDNA DKFZp451F1716 (from clone DKFZp451F1716). AB527207 - Synthetic construct DNA, clone: pF1KE0019, Homo sapiens RNF180 gene for ring finger protein 180, without stop codon, in Flexi system. AM393544 - Synthetic construct Homo sapiens clone IMAGE:100002245 for hypothetical protein (RNF180 gene). AK090756 - Homo sapiens cDNA FLJ33437 fis, clone BRACE2021541, weakly similar to PROTEIN-TYROSINE PHOSPHATASE YVH1 (EC 220.127.116.11). AX746601 - Sequence 126 from Patent EP1308459. BC101278 - Homo sapiens ring finger protein 180, mRNA (cDNA clone MGC:120326 IMAGE:40024390), complete cds. BC101279 - Homo sapiens ring finger protein 180, mRNA (cDNA clone IMAGE:40024391), complete cds. BC101277 - Homo sapiens ring finger protein 180, mRNA (cDNA clone MGC:120325 IMAGE:40024386), complete cds. BC101397 - Homo sapiens ring finger protein 180, mRNA (cDNA clone MGC:120328 IMAGE:40024392), complete cds. KJ896011 - Synthetic construct Homo sapiens clone ccsbBroadEn_05405 RNF180 gene, encodes complete protein. JD553401 - Sequence 534425 from Patent EP1572962. JD235101 - Sequence 216125 from Patent EP1572962. JD346165 - Sequence 327189 from Patent EP1572962. JD101734 - Sequence 82758 from Patent EP1572962. JD183525 - Sequence 164549 from Patent EP1572962. JD312927 - Sequence 293951 from Patent EP1572962. JD095737 - Sequence 76761 from Patent EP1572962. JD245940 - Sequence 226964 from Patent EP1572962. JD084636 - Sequence 65660 from Patent EP1572962. JD433764 - Sequence 414788 from Patent EP1572962. JD562709 - Sequence 543733 from Patent EP1572962. JD509545 - Sequence 490569 from Patent EP1572962. JD270980 - Sequence 252004 from Patent EP1572962. JD359294 - Sequence 340318 from Patent EP1572962. JD359233 - Sequence 340257 from Patent EP1572962. JD306087 - Sequence 287111 from Patent EP1572962. JD315610 - Sequence 296634 from Patent EP1572962. JD231202 - Sequence 212226 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: NM_001113561, NP_001107033, Q0JSU3, Q495A8, Q86T96, Q8NBD1, RN180_HUMAN UCSC ID: uc003jti.3 RefSeq Accession: NM_001113561
(aka RN180_HUMAN) Q86T96
Gene Model Information
8 CDS single in 3' UTR:
1779 CDS single in intron:
Alignment % ID:
3658.00 frame shift in genome:
has start codon:
stop codon in genome:
# of Alignments:
has end codon:
# AT/AC introns
end bleed into intron:
0 # strange splices:
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.