Human Gene C1QTNF7 (uc003gnp.3) Description and Page Index
  Description: Homo sapiens C1q and tumor necrosis factor related protein 7 (C1QTNF7), transcript variant 3, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr4:15,429,629-15,447,791 Size: 18,163 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr4:15,437,368-15,444,423 Size: 7,056 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:15,429,629-15,447,791)mRNA (may differ from genome)Protein (289 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: C1QT7_HUMAN
DESCRIPTION: RecName: Full=Complement C1q tumor necrosis factor-related protein 7; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted (Potential).
SIMILARITY: Contains 1 C1q domain.
SIMILARITY: Contains 1 collagen-like domain.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): C1QTNF7
CDC HuGE Published Literature: C1QTNF7
Positive Disease Associations: Conduct Disorder , Electrocardiography
Related Studies:
  1. Conduct Disorder
    D M Dick et al. Molecular psychiatry 2011, Genome-wide association study of conduct disorder symptomatology., Molecular psychiatry. [PubMed 20585324]
  2. Conduct Disorder
    D M Dick et al. Molecular psychiatry 2011, Genome-wide association study of conduct disorder symptomatology., Molecular psychiatry. [PubMed 20585324]
  3. Electrocardiography
    Christopher Newton-Cheh et al. BMC medical genetics 2007, Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study., BMC medical genetics. [PubMed 17903306]
    In the community-based Framingham Heart Study none of the ECG and HRV results individually attained genomewide significance. However, the presence of bona fide QT-associated SNPs among the top 117 results for QT duration supports the importance of efforts to validate top results from the reported scans. Finding genetic variants associated with ECG and HRV quantitative traits may identify novel genes and pathways implicated in arrhythmogenesis and allow for improved recognition of individuals at high risk for arrhythmias in the general population.
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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.81 RPKM in Artery - Tibial
Total median expression: 99.17 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -21.00110-0.191 Picture PostScript Text
3' UTR -879.763368-0.261 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001073 - C1q
IPR008160 - Collagen
IPR008983 - Tumour_necrosis_fac-like

Pfam Domains:
PF00386 - C1q domain
PF01391 - Collagen triple helix repeat (20 copies)

SCOP Domains:
49842 - TNF-like

ModBase Predicted Comparative 3D Structure on Q9BXJ2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005576 extracellular region
GO:0005581 collagen trimer


-  Descriptions from all associated GenBank mRNAs
  BX647781 - Homo sapiens mRNA; cDNA DKFZp686E1887 (from clone DKFZp686E1887).
AK314802 - Homo sapiens cDNA, FLJ95676, Homo sapiens C1q and tumor necrosis factor related protein 7 (C1QTNF7), mRNA.
BC022187 - Homo sapiens C1q and tumor necrosis factor related protein 7, mRNA (cDNA clone MGC:26871 IMAGE:4825040), complete cds.
BC024015 - Homo sapiens C1q and tumor necrosis factor related protein 7, mRNA (cDNA clone MGC:26966 IMAGE:4823626), complete cds.
AF329839 - Homo sapiens complement-c1q tumor necrosis factor-related protein (CTRP7) mRNA, complete cds.
GQ129405 - Synthetic construct Homo sapiens clone HAIB:100068507; DKFZo004F0134 C1q and tumor necrosis factor related protein 7 protein (C1QTNF7) gene, partial cds.
EU832817 - Synthetic construct Homo sapiens clone HAIB:100067846; DKFZo008F0133 C1q and tumor necrosis factor related protein 7 protein (C1QTNF7) gene, encodes complete protein.
JD385682 - Sequence 366706 from Patent EP1572962.
JD361296 - Sequence 342320 from Patent EP1572962.
JD361297 - Sequence 342321 from Patent EP1572962.
JD563804 - Sequence 544828 from Patent EP1572962.
JD301575 - Sequence 282599 from Patent EP1572962.
JD046499 - Sequence 27523 from Patent EP1572962.
JD246072 - Sequence 227096 from Patent EP1572962.
JD347532 - Sequence 328556 from Patent EP1572962.
JD309471 - Sequence 290495 from Patent EP1572962.
JD533412 - Sequence 514436 from Patent EP1572962.
JD469651 - Sequence 450675 from Patent EP1572962.
JD370122 - Sequence 351146 from Patent EP1572962.
JD486821 - Sequence 467845 from Patent EP1572962.
JD091687 - Sequence 72711 from Patent EP1572962.
JD241420 - Sequence 222444 from Patent EP1572962.
JD267806 - Sequence 248830 from Patent EP1572962.
JD064772 - Sequence 45796 from Patent EP1572962.
JD040137 - Sequence 21161 from Patent EP1572962.
JD440589 - Sequence 421613 from Patent EP1572962.
JD520004 - Sequence 501028 from Patent EP1572962.
JD114238 - Sequence 95262 from Patent EP1572962.
JD154158 - Sequence 135182 from Patent EP1572962.
JD291219 - Sequence 272243 from Patent EP1572962.
JD560257 - Sequence 541281 from Patent EP1572962.
JD473125 - Sequence 454149 from Patent EP1572962.
JD369580 - Sequence 350604 from Patent EP1572962.
JD480117 - Sequence 461141 from Patent EP1572962.
JD476305 - Sequence 457329 from Patent EP1572962.
JD476304 - Sequence 457328 from Patent EP1572962.
JD231095 - Sequence 212119 from Patent EP1572962.
JD247744 - Sequence 228768 from Patent EP1572962.
JD554572 - Sequence 535596 from Patent EP1572962.
JD168061 - Sequence 149085 from Patent EP1572962.
JD548879 - Sequence 529903 from Patent EP1572962.
JD483845 - Sequence 464869 from Patent EP1572962.
JD170945 - Sequence 151969 from Patent EP1572962.
JD168733 - Sequence 149757 from Patent EP1572962.
JD245340 - Sequence 226364 from Patent EP1572962.
JD441560 - Sequence 422584 from Patent EP1572962.
JD109691 - Sequence 90715 from Patent EP1572962.
JD465256 - Sequence 446280 from Patent EP1572962.
JD369787 - Sequence 350811 from Patent EP1572962.
JD099819 - Sequence 80843 from Patent EP1572962.
JD181757 - Sequence 162781 from Patent EP1572962.
JD531119 - Sequence 512143 from Patent EP1572962.
JD089205 - Sequence 70229 from Patent EP1572962.
JD264042 - Sequence 245066 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RBT3, C1QT7_HUMAN, CTRP7, NM_031911, NP_114117, Q9BXJ2
UCSC ID: uc003gnp.3
RefSeq Accession: NM_031911
Protein: Q9BXJ2 (aka C1QT7_HUMAN or CQT7_HUMAN)
CCDS: CCDS3414.1, CCDS47025.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_031911.4
exon count: 3CDS single in 3' UTR: no RNA size: 4360
ORF size: 870CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1904.50frame shift in genome: no % Coverage: 99.72
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.