Human Gene FOXS1 (uc002wwt.1) Description and Page Index
  Description: Homo sapiens forkhead box S1 (FOXS1), mRNA.
RefSeq Summary (NM_004118): The forkhead family of transcription factors belongs to the winged helix class of DNA-binding proteins. The protein encoded by this intronless gene contains a forkhead domain and is found predominantly in aorta and kidney. The function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: SRR3476690.946400.1, BC013408.2 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr20:30,432,103-30,433,420 Size: 1,318 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr20:30,432,353-30,433,345 Size: 993 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:30,432,103-30,433,420)mRNA (may differ from genome)Protein (330 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: FOXS1_HUMAN
DESCRIPTION: RecName: Full=Forkhead box protein S1; AltName: Full=Forkhead-like 18 protein; AltName: Full=Forkhead-related transcription factor 10; Short=FREAC-10;
FUNCTION: Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Contains 1 fork-head DNA-binding domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 23.93 RPKM in Artery - Coronary
Total median expression: 124.14 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -29.3075-0.391 Picture PostScript Text
3' UTR -106.19250-0.425 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001766 - TF_fork_head
IPR018122 - TF_fork_head_CS
IPR011991 - WHTH_trsnscrt_rep_DNA-bd

Pfam Domains:
PF00250 - Forkhead domain

SCOP Domains:
46785 - "Winged helix" DNA-binding domain

ModBase Predicted Comparative 3D Structure on O43638
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001568 blood vessel development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0009653 anatomical structure morphogenesis
GO:0030154 cell differentiation
GO:0040018 positive regulation of multicellular organism growth
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0050885 neuromuscular process controlling balance

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BC013408 - Homo sapiens forkhead box S1, mRNA (cDNA clone MGC:4544 IMAGE:3028182), complete cds.
JD097230 - Sequence 78254 from Patent EP1572962.
JD221555 - Sequence 202579 from Patent EP1572962.
JD383636 - Sequence 364660 from Patent EP1572962.
JD375233 - Sequence 356257 from Patent EP1572962.
BT009768 - Homo sapiens forkhead-like 18 (Drosophila) mRNA, complete cds.
KJ896822 - Synthetic construct Homo sapiens clone ccsbBroadEn_06216 FOXS1 gene, encodes complete protein.
DQ896105 - Synthetic construct Homo sapiens clone IMAGE:100010565; FLH190349.01L; RZPDo839H0465D forkhead-like 18 (Drosophila) (FKHL18) gene, encodes complete protein.
EU176391 - Synthetic construct Homo sapiens clone IMAGE:100006490; FLH190356.01X; RZPDo839D02252D forkhead-like 18 (Drosophila) (FKHL18) gene, encodes complete protein.
AB464535 - Synthetic construct DNA, clone: pF1KB9593, Homo sapiens FKHL18 gene for forkhead-like 18, without stop codon, in Flexi system.
AF042831 - Homo sapiens forkhead-related transcription factor FREAC-10 (FKHL18) mRNA, partial cds.
JD377869 - Sequence 358893 from Patent EP1572962.
JD405347 - Sequence 386371 from Patent EP1572962.
JD539360 - Sequence 520384 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: FKHL18, FOXS1_HUMAN, FREAC10, NM_004118, NP_004109, O43638, Q96D28
UCSC ID: uc002wwt.1
RefSeq Accession: NM_004118
Protein: O43638 (aka FOXS1_HUMAN)
CCDS: CCDS13192.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_004118.3
exon count: 1CDS single in 3' UTR: no RNA size: 1353
ORF size: 993CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2186.00frame shift in genome: no % Coverage: 97.41
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.