Human Gene FOXS1 (uc002wwt.1) Description and Page Index
Description: Homo sapiens forkhead box S1 (FOXS1), mRNA. RefSeq Summary (NM_004118): The forkhead family of transcription factors belongs to the winged helix class of DNA-binding proteins. The protein encoded by this intronless gene contains a forkhead domain and is found predominantly in aorta and kidney. The function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript is intronless :: SRR3476690.946400.1, BC013408.2 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr20:30,432,103-30,433,420 Size: 1,318 Total Exon Count: 1 Strand: - Coding Region Position: hg19 chr20:30,432,353-30,433,345 Size: 993 Coding Exon Count: 1
ID:FOXS1_HUMAN DESCRIPTION: RecName: Full=Forkhead box protein S1; AltName: Full=Forkhead-like 18 protein; AltName: Full=Forkhead-related transcription factor 10; Short=FREAC-10; FUNCTION: Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). SIMILARITY: Contains 1 fork-head DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43638
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001568 blood vessel development GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0009653 anatomical structure morphogenesis GO:0030154 cell differentiation GO:0040018 positive regulation of multicellular organism growth GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0045892 negative regulation of transcription, DNA-templated GO:0050885 neuromuscular process controlling balance