Human Gene NTF3 (uc001qnk.4) Description and Page Index
Description: Homo sapiens neurotrophin 3 (NTF3), transcript variant 1, mRNA. RefSeq Summary (NM_001102654): The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189652.232075.1, SRR3476690.165428.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000423158.4/ ENSP00000397297.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr12:5,541,280-5,604,465 Size: 63,186 Total Exon Count: 2 Strand: + Coding Region Position: hg19 chr12:5,541,491-5,604,154 Size: 62,664 Coding Exon Count: 2
Alzheimer's Disease Kunugi H et al. 1998, Possible association of missense mutation (Gly[-63]Glu) of the neurotrophin-3 gene with Alzheimer's disease in Japanese., Neuroscience letters. 1998 Jan;241(1):65-7.
schizophrenia Nanko S et al. 1994, Neurotrophin-3 gene polymorphism associated with schizophrenia, Acta psychiatrica Scandinavica. 1994 Jun;89(6):390-2.
schizophrenia Hattori M et al. 1995, Association of neurotrophin-3 gene variant with severe forms of schizophrenia., Biochemical and biophysical research communications. 1995 Apr;209(2):513-8.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00243 - Nerve growth factor family
ModBase Predicted Comparative 3D Structure on P20783-2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.