Human Gene TGM4 (uc003coc.4) Description and Page Index
  Description: Homo sapiens transglutaminase 4 (TGM4), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr3:44,916,098-44,956,088 Size: 39,991 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg19 chr3:44,916,171-44,955,217 Size: 39,047 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr3:44,916,098-44,956,088)mRNA (may differ from genome)Protein (684 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Protein-glutamine gamma-glutamyltransferase 4; EC=; AltName: Full=Fibrinoligase; AltName: Full=Prostate transglutaminase; AltName: Full=Prostate-specific transglutaminase; AltName: Full=Transglutaminase P; Short=TG(P); Short=TGP; Short=TGase P; AltName: Full=Transglutaminase-4; Short=TGase-4;
FUNCTION: Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.
CATALYTIC ACTIVITY: Protein glutamine + alkylamine = protein N(5)- alkylglutamine + NH(3).
COFACTOR: Binds 1 calcium ion per subunit (By similarity).
SUBUNIT: Homodimer (By similarity).
SIMILARITY: Belongs to the transglutaminase superfamily. Transglutaminase family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TGM4
CDC HuGE Published Literature: TGM4
Positive Disease Associations: Body Height
Related Studies:
  1. Body Height
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.88 RPKM in Prostate
Total median expression: 13.77 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -23.4073-0.321 Picture PostScript Text
3' UTR -286.00871-0.328 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023608 - Gln_gamma-glutamylTfrase_euk
IPR013783 - Ig-like_fold
IPR014756 - Ig_E-set
IPR002931 - Transglutaminase-like
IPR008958 - Transglutaminase_C
IPR013808 - Transglutaminase_CS
IPR001102 - Transglutaminase_N

Pfam Domains:
PF00868 - Transglutaminase family
PF00927 - Transglutaminase family, C-terminal ig like domain
PF01841 - Transglutaminase-like superfamily

SCOP Domains:
81296 - E set domains
49309 - Transglutaminase, two C-terminal domains
54001 - Cysteine proteinases

ModBase Predicted Comparative 3D Structure on P49221
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0046872 metal ion binding

Biological Process:
GO:0018149 peptide cross-linking

Cellular Component:
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0031012 extracellular matrix
GO:0070062 extracellular exosome

-  Descriptions from all associated GenBank mRNAs
  AK125536 - Homo sapiens cDNA FLJ43548 fis, clone PROST2017367, highly similar to PROTEIN-GLUTAMINE GLUTAMYLTRANSFERASE 4 (EC
AK312936 - Homo sapiens cDNA, FLJ93387, highly similar to Homo sapiens transglutaminase 4 (prostate) (TGM4), mRNA.
AK300523 - Homo sapiens cDNA FLJ58243 complete cds, highly similar to Protein-glutamine gamma-glutamyltransferase 4(EC
BC007003 - Homo sapiens transglutaminase 4 (prostate), mRNA (cDNA clone MGC:12298 IMAGE:3950865), complete cds.
U79008 - Human putative alternatively spliced prostate-specific transglutaminase (hTGP) mRNA, partial cds.
Y09559 - H.sapiens mRNA for prostate-specific transglutaminase.
L34840 - Homo sapiens transglutaminase mRNA, complete cds.
U31905 - Human prostate-specific transglutaminase (hTGP) mRNA, complete cds.
JD113793 - Sequence 94817 from Patent EP1572962.
CU675487 - Synthetic construct Homo sapiens gateway clone IMAGE:100018415 5' read TGM4 mRNA.
KJ897665 - Synthetic construct Homo sapiens clone ccsbBroadEn_07059 TGM4 gene, encodes complete protein.
DQ896505 - Synthetic construct Homo sapiens clone IMAGE:100010965; FLH194943.01L; RZPDo839G0970D transglutaminase 4 (prostate) (TGM4) gene, encodes complete protein.
EU176444 - Synthetic construct Homo sapiens clone IMAGE:100006520; FLH194950.01X; RZPDo839D08252D transglutaminase 4 (prostate) (TGM4) gene, encodes complete protein.
AK130286 - Homo sapiens cDNA FLJ26776 fis, clone PRS03665.
AK092657 - Homo sapiens cDNA FLJ35338 fis, clone PROST2015551.
JD561558 - Sequence 542582 from Patent EP1572962.
JD483180 - Sequence 464204 from Patent EP1572962.
JD370685 - Sequence 351709 from Patent EP1572962.
JD237002 - Sequence 218026 from Patent EP1572962.
JD227315 - Sequence 208339 from Patent EP1572962.
JD252737 - Sequence 233761 from Patent EP1572962.
JD553979 - Sequence 535003 from Patent EP1572962.
JD150224 - Sequence 131248 from Patent EP1572962.
JD311239 - Sequence 292263 from Patent EP1572962.
JD148770 - Sequence 129794 from Patent EP1572962.
JD232099 - Sequence 213123 from Patent EP1572962.
JD464857 - Sequence 445881 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_003241, NP_003232, P49221, Q16707, Q96QN4, TGM4_HUMAN
UCSC ID: uc003coc.4
RefSeq Accession: NM_003241
Protein: P49221 (aka TGM4_HUMAN)
CCDS: CCDS2723.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_003241.3
exon count: 14CDS single in 3' UTR: no RNA size: 3027
ORF size: 2055CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3529.00frame shift in genome: no % Coverage: 99.08
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.