ID:TGM4_HUMAN DESCRIPTION: RecName: Full=Protein-glutamine gamma-glutamyltransferase 4; EC=18.104.22.168; AltName: Full=Fibrinoligase; AltName: Full=Prostate transglutaminase; AltName: Full=Prostate-specific transglutaminase; AltName: Full=Transglutaminase P; Short=TG(P); Short=TGP; Short=TGase P; AltName: Full=Transglutaminase-4; Short=TGase-4; FUNCTION: Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract. CATALYTIC ACTIVITY: Protein glutamine + alkylamine = protein N(5)- alkylglutamine + NH(3). COFACTOR: Binds 1 calcium ion per subunit (By similarity). SUBUNIT: Homodimer (By similarity). TISSUE SPECIFICITY: Prostate. SIMILARITY: Belongs to the transglutaminase superfamily. Transglutaminase family.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): TGM4 CDC HuGE Published Literature: TGM4 Positive Disease Associations: Body Height Related Studies:
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00868 - Transglutaminase family PF00927 - Transglutaminase family, C-terminal ig like domain PF01841 - Transglutaminase-like superfamily
SCOP Domains: 81296 - E set domains 49309 - Transglutaminase, two C-terminal domains 54001 - Cysteine proteinases
ModBase Predicted Comparative 3D Structure on P49221
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.