Human Gene DCDC2B (uc001bun.2) Description and Page Index
  Description: Homo sapiens doublecortin domain containing 2B (DCDC2B), mRNA.
RefSeq Summary (NM_001099434): This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. [provided by RefSeq, Sep 2010]. ##Evidence-Data-START## Transcript exon combination :: BC128073.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr1:32,674,695-32,681,797 Size: 7,103 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr1:32,674,695-32,681,498 Size: 6,804 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:32,674,695-32,681,797)mRNA (may differ from genome)Protein (349 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
HGNCHPRDLynxMGIneXtProtPubMed
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: DCD2B_HUMAN
DESCRIPTION: RecName: Full=Doublecortin domain-containing protein 2B;
SIMILARITY: Contains 2 doublecortin domains.

-  MalaCards Disease Associations
  MalaCards Gene Search: DCDC2B
Diseases sorted by gene-association score: deafness, autosomal recessive 66 (4)

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.57 RPKM in Testis
Total median expression: 17.51 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -108.10299-0.362 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003533 - Doublecortin_dom

Pfam Domains:
PF03607 - Doublecortin

SCOP Domains:
89837 - Doublecortin (DC)

ModBase Predicted Comparative 3D Structure on A2VCK2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0035556 intracellular signal transduction

Cellular Component:
GO:0005622 intracellular


-  Descriptions from all associated GenBank mRNAs
  KJ895628 - Synthetic construct Homo sapiens clone ccsbBroadEn_05022 DCDC2B gene, encodes complete protein.
BC128073 - Homo sapiens doublecortin domain containing 2B, mRNA (cDNA clone MGC:148136 IMAGE:40109068), complete cds.
BC041458 - Homo sapiens doublecortin domain containing 2B, mRNA (cDNA clone IMAGE:5206208).
JD517020 - Sequence 498044 from Patent EP1572962.
JD383106 - Sequence 364130 from Patent EP1572962.
JD122898 - Sequence 103922 from Patent EP1572962.
JD528786 - Sequence 509810 from Patent EP1572962.
JD472058 - Sequence 453082 from Patent EP1572962.
JD075669 - Sequence 56693 from Patent EP1572962.
JD282278 - Sequence 263302 from Patent EP1572962.
JD364025 - Sequence 345049 from Patent EP1572962.
JD371846 - Sequence 352870 from Patent EP1572962.
JD243431 - Sequence 224455 from Patent EP1572962.
JD467057 - Sequence 448081 from Patent EP1572962.
JD372825 - Sequence 353849 from Patent EP1572962.
JD339368 - Sequence 320392 from Patent EP1572962.
JD060611 - Sequence 41635 from Patent EP1572962.
JD131700 - Sequence 112724 from Patent EP1572962.
JD414309 - Sequence 395333 from Patent EP1572962.
JD338310 - Sequence 319334 from Patent EP1572962.
JD317452 - Sequence 298476 from Patent EP1572962.
JD183684 - Sequence 164708 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A2VCK2, B7ZBC6, DCD2B_HUMAN, NM_001099434, NP_001092904
UCSC ID: uc001bun.2
RefSeq Accession: NM_001099434
Protein: A2VCK2 (aka DCD2B_HUMAN)
CCDS: CCDS44100.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001099434.1
exon count: 9CDS single in 3' UTR: no RNA size: 1367
ORF size: 1050CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2160.00frame shift in genome: no % Coverage: 98.68
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.