Human Gene LSM1 (uc003xkw.3) Description and Page Index
Description: Homo sapiens LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) (LSM1), transcript variant 1, mRNA. RefSeq Summary (NM_014462): This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]. Transcript (Including UTRs) Position: hg19 chr8:38,020,839-38,034,248 Size: 13,410 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr8:38,021,188-38,033,838 Size: 12,651 Coding Exon Count: 4
ID:LSM1_HUMAN DESCRIPTION: RecName: Full=U6 snRNA-associated Sm-like protein LSm1; AltName: Full=Cancer-associated Sm-like; AltName: Full=Small nuclear ribonuclear CaSm; FUNCTION: Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3'-terminal U-tract of U6 snRNA. SUBUNIT: Interacts with SLBP. Interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a doughnut shape. INTERACTION: Q9Y333:LSM2; NbExp=3; IntAct=EBI-347619, EBI-347416; P62310:LSM3; NbExp=3; IntAct=EBI-347619, EBI-348239; SUBCELLULAR LOCATION: Nucleus (Potential). TISSUE SPECIFICITY: Has elevated expression in pancreatic cancer and in several cancer-derived cell lines. SIMILARITY: Belongs to the snRNP Sm proteins family.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): LSM1 CDC HuGE Published Literature: LSM1 Positive Disease Associations: Schizophrenia Related Studies:
Schizophrenia Yongyong Shi et al. Nature genetics 2011, Common variants on 8p12 and 1q24.2 confer risk of schizophrenia., Nature genetics.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O15116
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.