Human Gene POLD2 (uc003tkf.5) Description and Page Index
Description: Homo sapiens polymerase (DNA directed), delta 2, accessory subunit (POLD2), transcript variant 2, mRNA. RefSeq Summary (NM_006230): This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]. Transcript (Including UTRs) Position: hg19 chr7:44,154,279-44,163,169 Size: 8,891 Total Exon Count: 11 Strand: - Coding Region Position: hg19 chr7:44,154,384-44,163,158 Size: 8,775 Coding Exon Count: 11
ID:DPOD2_HUMAN DESCRIPTION: RecName: Full=DNA polymerase delta subunit 2; EC=18.104.22.168; AltName: Full=DNA polymerase delta subunit p50; FUNCTION: The function of the small subunit is not yet clear. CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). SUBUNIT: Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with KCTD10 (By similarity). Interacts with KCTD13/POLDIP1, POLDIP2 and POLDIP3. Interacts with WRNIP1. Interacts with POLD4. INTERACTION: P28340:POLD1; NbExp=9; IntAct=EBI-372354, EBI-716569; Q15054:POLD3; NbExp=5; IntAct=EBI-372354, EBI-864956; Q9HCU8:POLD4; NbExp=3; IntAct=EBI-372354, EBI-864968; SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the DNA polymerase delta/II small subunit family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/pold2/";
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): POLD2 CDC HuGE Published Literature: POLD2
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P49005
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000723 telomere maintenance GO:0006260 DNA replication GO:0006271 DNA strand elongation involved in DNA replication GO:0006281 DNA repair GO:0006283 transcription-coupled nucleotide-excision repair GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion GO:0006297 nucleotide-excision repair, DNA gap filling GO:0006974 cellular response to DNA damage stimulus GO:0019985 translesion synthesis GO:0032201 telomere maintenance via semi-conservative replication GO:0033683 nucleotide-excision repair, DNA incision GO:0042769 DNA damage response, detection of DNA damage