Human Gene THAP4 (uc002wbt.3) Description and Page Index
Description: Homo sapiens THAP domain containing 4 (THAP4), transcript variant 1, mRNA.
Transcript (Including UTRs)
Position: hg19 chr2:242,523,820-242,576,725 Size: 52,906 Total Exon Count: 6 Strand: -
Position: hg19 chr2:242,524,021-242,576,432 Size: 52,412 Coding Exon Count: 6
Data last updated: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=THAP domain-containing protein 4;
SUBUNIT: Homodimer (Probable). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 THAP-type zinc finger. SEQUENCE CAUTION: Sequence=AAH00247.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH09439.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA91560.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive):
THAP4 CDC HuGE Published Literature:
THAP4 Positive Disease Associations: Brain structure
Brain structure Stein ,et al. Neuroimage 2010, Voxelwise Genome-Wide Association Study , NeuroImage 2010 .
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011038 - Calycin-like
IPR014878 - DUF1794
IPR006612 - Znf_C2CH
Pfam Domains: PF05485 - THAP domain
PF08768 - Domain of unknown function (DUF1794)
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on Q8WY91
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK225608 - Homo sapiens mRNA for THAP domain containing 4 variant, clone: REC02241. LF383626 - JP 2014500723-A/191129: Polycomb-Associated Non-Coding RNAs. BC071896 - Homo sapiens THAP domain containing 4, mRNA (cDNA clone IMAGE:6088454), partial cds. BC094822 - Homo sapiens THAP domain containing 4, mRNA (cDNA clone IMAGE:6214144), partial cds. AF258556 - Homo sapiens PP238 mRNA, complete cds. BC069235 - Homo sapiens THAP domain containing 4, mRNA (cDNA clone MGC:78456 IMAGE:6645198), complete cds. AK001216 - Homo sapiens cDNA FLJ10354 fis, clone NT2RM2001194. AF132970 - Homo sapiens CGI-36 protein mRNA, complete cds. BC000767 - Homo sapiens THAP domain containing 4, mRNA (cDNA clone IMAGE:2961488), complete cds. BC001842 - Homo sapiens THAP domain containing 4, mRNA (cDNA clone IMAGE:2961488), complete cds. BC000247 - Homo sapiens THAP domain containing 4, mRNA (cDNA clone IMAGE:3356125), complete cds. BC009439 - Homo sapiens THAP domain containing 4, mRNA (cDNA clone IMAGE:3508461), complete cds. GQ901007 - Homo sapiens clone HEL-T-119 epididymis secretory sperm binding protein mRNA, complete cds. JD224753 - Sequence 205777 from Patent EP1572962. JD246396 - Sequence 227420 from Patent EP1572962. KJ902548 - Synthetic construct Homo sapiens clone ccsbBroadEn_11942 THAP4 gene, encodes complete protein. KJ902549 - Synthetic construct Homo sapiens clone ccsbBroadEn_11943 THAP4 gene, encodes complete protein. LF319115 - JP 2014500723-A/126618: Polycomb-Associated Non-Coding RNAs. LF319116 - JP 2014500723-A/126619: Polycomb-Associated Non-Coding RNAs. JD382496 - Sequence 363520 from Patent EP1572962. JD310857 - Sequence 291881 from Patent EP1572962. JD040724 - Sequence 21748 from Patent EP1572962. LF319117 - JP 2014500723-A/126620: Polycomb-Associated Non-Coding RNAs. JD044878 - Sequence 25902 from Patent EP1572962. JD315490 - Sequence 296514 from Patent EP1572962. JD404565 - Sequence 385589 from Patent EP1572962. JD492686 - Sequence 473710 from Patent EP1572962. JD128615 - Sequence 109639 from Patent EP1572962. LF319118 - JP 2014500723-A/126621: Polycomb-Associated Non-Coding RNAs. JD404803 - Sequence 385827 from Patent EP1572962. JD302135 - Sequence 283159 from Patent EP1572962. JD454726 - Sequence 435750 from Patent EP1572962. MA619203 - JP 2018138019-A/191129: Polycomb-Associated Non-Coding RNAs. MA554692 - JP 2018138019-A/126618: Polycomb-Associated Non-Coding RNAs. MA554693 - JP 2018138019-A/126619: Polycomb-Associated Non-Coding RNAs. MA554694 - JP 2018138019-A/126620: Polycomb-Associated Non-Coding RNAs. MA554695 - JP 2018138019-A/126621: Polycomb-Associated Non-Coding RNAs.
Other Names for This Gene
Alternate Gene Symbols: CGI-36, NM_015963, NP_057047, PP238, Q53NU7, Q6GRN0, Q6IPJ3, Q8WY91, Q9NW26, Q9Y325, THAP4_HUMAN UCSC ID: uc002wbt.3 RefSeq Accession: NM_015963
(aka THAP4_HUMAN or THA4_HUMAN) Q8WY91
Gene Model Information
6 CDS single in 3' UTR:
1734 CDS single in intron:
Alignment % ID:
3263.00 frame shift in genome:
has start codon:
stop codon in genome:
# of Alignments:
has end codon:
# AT/AC introns
end bleed into intron:
0 # strange splices:
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.