Human Gene RAB11A (uc002apk.3) Description and Page Index
  Description: Homo sapiens RAB11A, member RAS oncogene family (RAB11A), transcript variant 1, mRNA.
RefSeq Summary (NM_004663): The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].
Transcript (Including UTRs)
   Position: hg19 chr15:66,161,797-66,184,329 Size: 22,533 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr15:66,161,924-66,180,178 Size: 18,255 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:66,161,797-66,184,329)mRNA (may differ from genome)Protein (216 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedReactomeStanford SOURCETreefam
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: RB11A_HUMAN
DESCRIPTION: RecName: Full=Ras-related protein Rab-11A; Short=Rab-11; AltName: Full=YL8; Flags: Precursor;
FUNCTION: Regulates endocytic recycling. May exert its functions by interacting with multiple effector proteins in different complexes. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes (By similarity).
SUBUNIT: Interacts with RIP11 and STXBP6. Interacts with SGSM1, SGSM2 and SGSM3 (By similarity). Interacts with EXOC6 in a GTP- dependent manner (By similarity). Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with VIPAS39. Interacts with MYO5B. Found in a complex with MYO5B and CFTR. Interacts with NPC1L1. Interacts (GDP-bound form) with ZFYVE27. Interacts with BIRC6/bruce.
INTERACTION: Q7L804:RAB11FIP2; NbExp=2; IntAct=EBI-745098, EBI-1049676; Q5T4F4:ZFYVE27; NbExp=4; IntAct=EBI-745098, EBI-3892947;
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Cleavage furrow. Note=Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Localizes to the cleavage furrow. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and luminogenesis.
SIMILARITY: Belongs to the small GTPase superfamily. Rab family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): RAB11A
CDC HuGE Published Literature: RAB11A

-  MalaCards Disease Associations
  MalaCards Gene Search: RAB11A
Diseases sorted by gene-association score: barrett esophagus/esophageal adenocarcinoma (2), functional diarrhea (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 48.10 RPKM in Esophagus - Mucosa
Total median expression: 1053.66 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -49.34127-0.389 Picture PostScript Text
3' UTR -1110.274151-0.267 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005225 - Small_GTP-bd_dom
IPR001806 - Small_GTPase
IPR003579 - Small_GTPase_Rab_type

Pfam Domains:
PF00025 - ADP-ribosylation factor family
PF00071 - Ras family
PF01926 - 50S ribosome-binding GTPase
PF08477 - Ras of Complex, Roc, domain of DAPkinase

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1OIV
- X-ray MuPIT

1OIW
- X-ray MuPIT

1OIX
- X-ray MuPIT
To conserve bandwidth, only the images from the first 3 structures are shown.
1YZK - X-ray MuPIT 2D7C - X-ray MuPIT 2GZD - X-ray MuPIT
2GZH - X-ray MuPIT 2HV8 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P62491
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsemblFlyBaseWormBase 
 Protein SequenceProtein SequenceProtein SequenceProtein Sequence 
 AlignmentAlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008017 microtubule binding
GO:0019905 syntaxin binding
GO:0031489 myosin V binding

Biological Process:
GO:0003091 renal water homeostasis
GO:0007049 cell cycle
GO:0007080 mitotic metaphase plate congression
GO:0010634 positive regulation of epithelial cell migration
GO:0010796 regulation of multivesicular body size
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0030953 astral microtubule organization
GO:0031175 neuron projection development
GO:0032402 melanosome transport
GO:0032465 regulation of cytokinesis
GO:0036258 multivesicular body assembly
GO:0043687 post-translational protein modification
GO:0045773 positive regulation of axon extension
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048227 plasma membrane to endosome transport
GO:0051223 regulation of protein transport
GO:0051650 establishment of vesicle localization
GO:0060627 regulation of vesicle-mediated transport
GO:0072594 establishment of protein localization to organelle
GO:0072659 protein localization to plasma membrane
GO:0090150 establishment of protein localization to membrane
GO:0090307 mitotic spindle assembly
GO:0097711 ciliary basal body docking
GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1990182 exosomal secretion

Cellular Component:
GO:0000922 spindle pole
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005771 multivesicular body
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030133 transport vesicle
GO:0030424 axon
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0031982 vesicle
GO:0032154 cleavage furrow
GO:0032991 macromolecular complex
GO:0043231 intracellular membrane-bounded organelle
GO:0045335 phagocytic vesicle
GO:0048471 perinuclear region of cytoplasm
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:0070062 extracellular exosome
GO:0098837 postsynaptic recycling endosome
GO:0005813 centrosome
GO:0005828 kinetochore microtubule


-  Descriptions from all associated GenBank mRNAs
  AK297549 - Homo sapiens cDNA FLJ61136 complete cds, highly similar to Ras-related protein Rab-11A.
AK298961 - Homo sapiens cDNA FLJ57160 complete cds, highly similar to Ras-related protein Rab-11A.
AK311770 - Homo sapiens cDNA, FLJ92031, Homo sapiens RAB11A, member RAS oncogene family (RAB11A), mRNA.
BC013348 - Homo sapiens RAB11A, member RAS oncogene family, mRNA (cDNA clone MGC:1490 IMAGE:3510339), complete cds.
AF000231 - Homo sapiens rab11a GTPase mRNA, complete cds.
JD427006 - Sequence 408030 from Patent EP1572962.
X56740 - H.sapiens mRNA for Rab11 gene.
AK300008 - Homo sapiens cDNA FLJ51542 complete cds, highly similar to Ras-related protein Rab-11B.
DL492121 - Novel nucleic acids.
CR407669 - Homo sapiens full open reading frame cDNA clone RZPDo834B053D for gene RAB11A, RAB11A, member RAS oncogene family complete cds, without stopcodon.
DQ896303 - Synthetic construct Homo sapiens clone IMAGE:100010763; FLH193100.01L; RZPDo839C1268D RAB11A, member RAS oncogene family (RAB11A) gene, encodes complete protein.
BT020151 - Homo sapiens RAB11A, member RAS oncogene family mRNA, complete cds.
BT020154 - Homo sapiens RAB11A, member RAS oncogene family mRNA, complete cds.
DQ893054 - Synthetic construct clone IMAGE:100005684; FLH193104.01X; RZPDo839C1278D RAB11A, member RAS oncogene family (RAB11A) gene, encodes complete protein.
KJ892615 - Synthetic construct Homo sapiens clone ccsbBroadEn_02009 RAB11A gene, encodes complete protein.
AF498946 - Homo sapiens small GTP binding protein RAB11A (RAB11A) mRNA, complete cds.
CR536493 - Homo sapiens full open reading frame cDNA clone RZPDo834F1017D for gene RAB11A, RAB11A, member RAS oncogene family; complete cds, incl. stopcodon.
X53143 - Human YL8 mRNA for ras-like protein.
DL490657 - Novel nucleic acids.
JD019002 - Sequence 26 from Patent EP1572962.
JD032833 - Sequence 13857 from Patent EP1572962.
JD045220 - Sequence 26244 from Patent EP1572962.
JD435790 - Sequence 416814 from Patent EP1572962.
JD494523 - Sequence 475547 from Patent EP1572962.
JD094311 - Sequence 75335 from Patent EP1572962.
JD313373 - Sequence 294397 from Patent EP1572962.
JD147871 - Sequence 128895 from Patent EP1572962.
JD545545 - Sequence 526569 from Patent EP1572962.
JD152524 - Sequence 133548 from Patent EP1572962.
JD509214 - Sequence 490238 from Patent EP1572962.
JD346022 - Sequence 327046 from Patent EP1572962.
JD088798 - Sequence 69822 from Patent EP1572962.
JD256552 - Sequence 237576 from Patent EP1572962.
JD476736 - Sequence 457760 from Patent EP1572962.
JD414849 - Sequence 395873 from Patent EP1572962.
JD379695 - Sequence 360719 from Patent EP1572962.
JD311826 - Sequence 292850 from Patent EP1572962.
JD081627 - Sequence 62651 from Patent EP1572962.
JD081628 - Sequence 62652 from Patent EP1572962.
BC047114 - Homo sapiens cDNA clone IMAGE:5313062.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04144 - Endocytosis
hsa04962 - Vasopressin-regulated water reabsorption

BioCyc Knowledge Library
PWY3DJ-1 - cyclic AMP biosynthesis

BioCarta from NCI Cancer Genome Anatomy Project
h_rabPathway - Rab GTPases Mark Targets In The Endocytotic Machinery

Reactome (by CSHL, EBI, and GO)

Protein P62491 (Reactome details) participates in the following event(s):

R-HSA-8854759 TBC1D14 binds RAB11 and ULK1
R-HSA-5620921 ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex
R-HSA-5623513 ASAP1 stimulates GTPase activity of ARF4
R-HSA-5623519 RAB3IP and RAB8A bind to the ciliary targeting complex
R-HSA-5638014 RAB11A:GTP-containing Golgi vesicles recruit RAB3IP
R-HSA-8870466 RGGT:CHM binds RABs
R-HSA-5623521 RAB3IP stimulates nucleotide exchange on RAB8A
R-HSA-5623524 The exocyst complex binds to RAB3IP in the ciliary targeting complex
R-HSA-5638009 CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
R-HSA-8870469 RGGT geranylgeranylates RAB proteins
R-HSA-5617816 RAB3IP stimulates nucleotide exchange on RAB8A
R-HSA-8854214 TBC/RABGAPs
R-HSA-5620916 VxPx cargo-targeting to cilium
R-HSA-9007101 Rab regulation of trafficking
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5620920 Cargo trafficking to the periciliary membrane
R-HSA-8873719 RAB geranylgeranylation
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-199991 Membrane Trafficking
R-HSA-5617833 Cilium Assembly
R-HSA-597592 Post-translational protein modification
R-HSA-445717 Aquaporin-mediated transport
R-HSA-5653656 Vesicle-mediated transport
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-392499 Metabolism of proteins
R-HSA-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: B2R4B6, NM_004663, NP_004654, P24410, P62491, Q5TZN9, Q9JLX1, RAB11, RB11A_HUMAN
UCSC ID: uc002apk.3
RefSeq Accession: NM_004663
Protein: P62491 (aka RB11A_HUMAN or R11A_HUMAN)
CCDS: CCDS10212.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_004663.4
exon count: 5CDS single in 3' UTR: no RNA size: 4943
ORF size: 651CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1502.00frame shift in genome: no % Coverage: 99.72
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.