Human Gene HNRNPL (uc010xun.2) Description and Page Index
Description: Homo sapiens heterogeneous nuclear ribonucleoprotein L (HNRNPL), transcript variant 2, mRNA. RefSeq Summary (NM_001005335): Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr19:39,330,736-39,334,744 Size: 4,009 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr19:39,330,786-39,332,255 Size: 1,470 Coding Exon Count: 3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
X16135 - Human mRNA for novel heterogeneous nuclear RNP protein, L protein. AK292115 - Homo sapiens cDNA FLJ75895 complete cds, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein L (HNRPL), transcript variant 2, mRNA. BC069184 - Homo sapiens heterogeneous nuclear ribonucleoprotein L, mRNA (cDNA clone IMAGE:6174088), partial cds. AB044547 - Homo sapiens P/OKcl.14 mRNA for heterogeneous nuclear ribonucleoprotein L, complete cds. GQ900947 - Homo sapiens clone HEL-T-59 epididymis secretory sperm binding protein mRNA, complete cds. AK092828 - Homo sapiens cDNA FLJ35509 fis, clone SPLEN1000041, highly similar to HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN L. AK094966 - Homo sapiens cDNA FLJ37647 fis, clone BRHIP2000445, highly similar to HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN L. AK313652 - Homo sapiens cDNA, FLJ94229, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein L (HNRPL),mRNA. AB587509 - Synthetic construct DNA, clone: pF1KB9904, Homo sapiens HNRNPL gene for heterogeneous nuclear ribonucleoprotein L, without stop codon, in Flexi system. AY927544 - Homo sapiens mRNA sequence. AK301062 - Homo sapiens cDNA FLJ60000 complete cds, highly similar to Heterogeneous nuclear ribonucleoprotein L. AK298384 - Homo sapiens cDNA FLJ55127 complete cds, highly similar to Heterogeneous nuclear ribonucleoprotein L.