Human Gene CLTA (uc003zzc.3) Description and Page Index
Description: Homo sapiens clathrin, light chain A (CLTA), transcript variant 2, mRNA. RefSeq Summary (NM_007096): Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, May 2010]. Transcript (Including UTRs) Position: hg19 chr9:36,190,853-36,212,059 Size: 21,207 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chr9:36,191,054-36,211,771 Size: 20,718 Coding Exon Count: 7
ID:CLCA_HUMAN DESCRIPTION: RecName: Full=Clathrin light chain A; Short=Lca; FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. SUBUNIT: Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts with CALY; the interaction stimulates clathrin self-assembly and clathrin- mediated endocytosis. SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles. SIMILARITY: Belongs to the clathrin light chain family.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): CLTA CDC HuGE Published Literature: CLTA Positive Disease Associations: smoking cessation Related Studies:
smoking cessation Uhl ,et al. Pharmacogenomics 2010, Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement , Pharmacogenomics 2010 11- 3 : 357-67.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P09496
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.