Human Gene UBE2D3 (uc003hwl.3) Description and Page Index
Description: Homo sapiens ubiquitin-conjugating enzyme E2D 3 (UBE2D3), transcript variant 7, mRNA. RefSeq Summary (NM_181891): The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. [provided by RefSeq, Jan 2017]. Transcript (Including UTRs) Position: hg19 chr4:103,717,133-103,748,708 Size: 31,576 Total Exon Count: 8 Strand: - Coding Region Position: hg19 chr4:103,718,572-103,747,665 Size: 29,094 Coding Exon Count: 7
ID:UB2D3_HUMAN DESCRIPTION: RecName: Full=Ubiquitin-conjugating enzyme E2 D3; EC=22.214.171.124; AltName: Full=Ubiquitin carrier protein D3; AltName: Full=Ubiquitin-conjugating enzyme E2(17)KB 3; AltName: Full=Ubiquitin-conjugating enzyme E2-17 kDa 3; AltName: Full=Ubiquitin-protein ligase D3; FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA- linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML- NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction (By similarity). CATALYTIC ACTIVITY: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex; when Cullin is neddylated, the interaction between the E2 and the SCF complex is strengthened. Interacts with DAPK3. Interacts with BRCA1; the DNA damage checkpoint promotes the association with BRCA1 after ionizing radiation. Interacts non- covalently with ubiquitin. INTERACTION: Q9Y3C5:RNF11; NbExp=3; IntAct=EBI-348268, EBI-396669; Q9BV68:RNF126; NbExp=3; IntAct=EBI-348268, EBI-357322; Q68DV7:RNF43; NbExp=2; IntAct=EBI-348268, EBI-1647060; Q99942:RNF5; NbExp=3; IntAct=EBI-348268, EBI-348482; Q9Y4K3:TRAF6; NbExp=2; IntAct=EBI-348268, EBI-359276; P98170:XIAP; NbExp=2; IntAct=EBI-348268, EBI-517127; Q8ND25:ZNRF1; NbExp=3; IntAct=EBI-348268, EBI-2129250; SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): UBE2D3 CDC HuGE Published Literature: UBE2D3 Positive Disease Associations: Diabetes Mellitus Related Studies:
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P61077
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.