Human Gene RBM39 (uc002xeb.3) Description and Page Index
Description: Homo sapiens RNA binding motif protein 39 (RBM39), transcript variant 1, mRNA. RefSeq Summary (NM_184234): This gene encodes a member of the U2AF65 family of proteins. The encoded protein is found in the nucleus, where it co-localizes with core spliceosomal proteins. It has been shown to play a role in both steroid hormone receptor-mediated transcription and alternative splicing, and it is also a transcriptional coregulator of the viral oncoprotein v-Rel. Multiple transcript variants have been observed for this gene. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Aug 2011]. Transcript (Including UTRs) Position: hg19 chr20:34,291,531-34,330,258 Size: 38,728 Total Exon Count: 17 Strand: - Coding Region Position: hg19 chr20:34,292,403-34,328,796 Size: 36,394 Coding Exon Count: 16
ID:RBM39_HUMAN DESCRIPTION: RecName: Full=RNA-binding protein 39; AltName: Full=Hepatocellular carcinoma protein 1; AltName: Full=RNA-binding motif protein 39; AltName: Full=RNA-binding region-containing protein 2; AltName: Full=Splicing factor HCC1; FUNCTION: Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process. SUBUNIT: Interacts with NCOA6 (By similarity). Interacts with RSRC1 (via Arg/Ser-rich domain). SUBCELLULAR LOCATION: Nucleus speckle. Note=Concentrated in nuclear speckles. Colocalizes with the core spliceosomal snRNP proteins. TISSUE SPECIFICITY: Widely expressed. Highly expressed in pancreas, skeletal muscle, lung and brain. Expressed at intermediate level in kidney, liver and heart. MISCELLANEOUS: Antibodies against RNPC2 are present in sera from a patient with hepatocellular carcinoma who developed several autoantibodies. SIMILARITY: Belongs to the splicing factor SR family. SIMILARITY: Contains 3 RRM (RNA recognition motif) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14498
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.