Human Gene AAMP (uc002vhk.3) Description and Page Index
Description: Homo sapiens angio-associated, migratory cell protein (AAMP), mRNA. RefSeq Summary (NM_001087): The gene is a member of the immunoglobulin superfamily. The encoded protein is associated with angiogenesis, with potential roles in endothelial tube formation and the migration of endothelial cells. It may also regulate smooth muscle cell migration via the RhoA pathway. The encoded protein can bind to heparin and may mediate heparin-sensitive cell adhesion. [provided by RefSeq, Oct 2014]. Transcript (Including UTRs) Position: hg19 chr2:219,128,852-219,134,893 Size: 6,042 Total Exon Count: 11 Strand: - Coding Region Position: hg19 chr2:219,129,256-219,134,809 Size: 5,554 Coding Exon Count: 11
ID:AAMP_HUMAN DESCRIPTION: RecName: Full=Angio-associated migratory cell protein; FUNCTION: Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway. SUBCELLULAR LOCATION: Cell membrane. Cytoplasm. TISSUE SPECIFICITY: Expressed in metastatic melanoma, liver, skin, kidney, heart, lung, lymph node, skeletal muscle and brain, and also in A2058 melanoma cells and activated T-cells (at protein level). Expressed in blood vessels. Strongly expressed in endothelial cells, cytotrophoblasts, and poorly differentiated. colon adenocarcinoma cells found in lymphatics. SIMILARITY: Contains 8 WD repeats. SEQUENCE CAUTION: Sequence=AAA68889.1; Type=Erroneous initiation; Sequence=CAG33036.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13685
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.