Human Gene AAMP (uc002vhk.3) Description and Page Index
  Description: Homo sapiens angio-associated, migratory cell protein (AAMP), mRNA.
RefSeq Summary (NM_001087): The gene is a member of the immunoglobulin superfamily. The encoded protein is associated with angiogenesis, with potential roles in endothelial tube formation and the migration of endothelial cells. It may also regulate smooth muscle cell migration via the RhoA pathway. The encoded protein can bind to heparin and may mediate heparin-sensitive cell adhesion. [provided by RefSeq, Oct 2014].
Transcript (Including UTRs)
   Position: hg19 chr2:219,128,852-219,134,893 Size: 6,042 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr2:219,129,256-219,134,809 Size: 5,554 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:219,128,852-219,134,893)mRNA (may differ from genome)Protein (434 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: AAMP_HUMAN
DESCRIPTION: RecName: Full=Angio-associated migratory cell protein;
FUNCTION: Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway.
SUBCELLULAR LOCATION: Cell membrane. Cytoplasm.
TISSUE SPECIFICITY: Expressed in metastatic melanoma, liver, skin, kidney, heart, lung, lymph node, skeletal muscle and brain, and also in A2058 melanoma cells and activated T-cells (at protein level). Expressed in blood vessels. Strongly expressed in endothelial cells, cytotrophoblasts, and poorly differentiated. colon adenocarcinoma cells found in lymphatics.
SIMILARITY: Contains 8 WD repeats.
SEQUENCE CAUTION: Sequence=AAA68889.1; Type=Erroneous initiation; Sequence=CAG33036.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 69.96 RPKM in Ovary
Total median expression: 2282.50 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -33.3084-0.396 Picture PostScript Text
3' UTR -159.80404-0.396 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR019775 - WD40_repeat_CS
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00400 - WD domain, G-beta repeat

SCOP Domains:
50952 - Soluble quinoprotein glucose dehydrogenase
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Prolyl oligopeptidase, N-terminal domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - Dipeptidyl peptidase IV/CD26, N-terminal domain

ModBase Predicted Comparative 3D Structure on Q13685
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008201 heparin binding
GO:0051082 unfolded protein binding

Biological Process:
GO:0001525 angiogenesis
GO:0007275 multicellular organism development
GO:0010595 positive regulation of endothelial cell migration
GO:0014909 smooth muscle cell migration
GO:0030154 cell differentiation
GO:0042273 ribosomal large subunit biogenesis

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0030687 preribosome, large subunit precursor
GO:0045171 intercellular bridge


-  Descriptions from all associated GenBank mRNAs
  AK131047 - Homo sapiens cDNA FLJ29013 fis, clone DMC08815, highly similar to Angio-associated migratory cell protein.
BC020244 - Homo sapiens, Similar to angio-associated, migratory cell protein, clone IMAGE:3927978, mRNA, partial cds.
BC014122 - Homo sapiens angio-associated, migratory cell protein, mRNA (cDNA clone IMAGE:4552582), containing frame-shift errors.
AK225078 - Homo sapiens mRNA for angio-associated, migratory cell protein variant, clone: CAE07232.
BC039866 - Homo sapiens angio-associated, migratory cell protein, mRNA (cDNA clone MGC:49017 IMAGE:6049156), complete cds.
AB209790 - Homo sapiens mRNA for angio-associated, migratory cell protein variant protein.
M95627 - Homo sapiens angio-associated migratory cell protein (AAMP) mRNA, complete cds.
BC008809 - Homo sapiens angio-associated, migratory cell protein, mRNA (cDNA clone IMAGE:3951873), partial cds.
JD077670 - Sequence 58694 from Patent EP1572962.
JD059279 - Sequence 40303 from Patent EP1572962.
JD265599 - Sequence 246623 from Patent EP1572962.
JD436390 - Sequence 417414 from Patent EP1572962.
JD316996 - Sequence 298020 from Patent EP1572962.
JD493902 - Sequence 474926 from Patent EP1572962.
JD342956 - Sequence 323980 from Patent EP1572962.
JD233370 - Sequence 214394 from Patent EP1572962.
JD104595 - Sequence 85619 from Patent EP1572962.
JD499499 - Sequence 480523 from Patent EP1572962.
CR456755 - Homo sapiens full open reading frame cDNA clone RZPDo834B014D for gene AAMP, angio-associated, migratory cell protein; complete cds, incl. stopcodon.
KJ901274 - Synthetic construct Homo sapiens clone ccsbBroadEn_10668 AAMP gene, encodes complete protein.
LF205245 - JP 2014500723-A/12748: Polycomb-Associated Non-Coding RNAs.
LF318566 - JP 2014500723-A/126069: Polycomb-Associated Non-Coding RNAs.
LF318567 - JP 2014500723-A/126070: Polycomb-Associated Non-Coding RNAs.
MA440822 - JP 2018138019-A/12748: Polycomb-Associated Non-Coding RNAs.
MA554143 - JP 2018138019-A/126069: Polycomb-Associated Non-Coding RNAs.
MA554144 - JP 2018138019-A/126070: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: AAMP_HUMAN, NM_001087, NP_001078, Q13685, Q8WUJ9, Q96H92
UCSC ID: uc002vhk.3
RefSeq Accession: NM_001087
Protein: Q13685 (aka AAMP_HUMAN)
CCDS: CCDS33378.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001087.3
exon count: 11CDS single in 3' UTR: no RNA size: 1859
ORF size: 1305CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2810.00frame shift in genome: no % Coverage: 96.45
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.