Human Gene TMEM109 (uc001nqg.3) Description and Page Index
  Description: Homo sapiens transmembrane protein 109 (TMEM109), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:60,681,371-60,690,915 Size: 9,545 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr11:60,687,166-60,689,637 Size: 2,472 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:60,681,371-60,690,915)mRNA (may differ from genome)Protein (243 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Transmembrane protein 109; AltName: Full=Mitsugumin-23; Short=Mg23; Flags: Precursor;
SUBCELLULAR LOCATION: Nucleus outer membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum membrane; Multi- pass membrane protein (By similarity). Sarcoplasmic reticulum membrane; Multi-pass membrane protein (By similarity).

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 82.77 RPKM in Uterus
Total median expression: 2197.62 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -127.90378-0.338 Picture PostScript Text
3' UTR -486.351278-0.381 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF14965 - Negative regulator of p53/TP53

ModBase Predicted Comparative 3D Structure on Q9BVC6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0005244 voltage-gated ion channel activity

Biological Process:
GO:0006811 ion transport
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0060548 negative regulation of cell death
GO:0071480 cellular response to gamma radiation

Cellular Component:
GO:0005634 nucleus
GO:0005640 nuclear outer membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016529 sarcoplasmic reticulum
GO:0033017 sarcoplasmic reticulum membrane
GO:0070062 extracellular exosome

-  Descriptions from all associated GenBank mRNAs
  LF211255 - JP 2014500723-A/18758: Polycomb-Associated Non-Coding RNAs.
AK303961 - Homo sapiens cDNA FLJ57860 complete cds, highly similar to Transmembrane protein 109 precursor.
AK313913 - Homo sapiens cDNA, FLJ94551.
AX775851 - Sequence 121 from Patent WO03048202.
BC001309 - Homo sapiens transmembrane protein 109, mRNA (cDNA clone MGC:5508 IMAGE:3453616), complete cds.
AX775849 - Sequence 119 from Patent WO03048202.
MA446832 - JP 2018138019-A/18758: Polycomb-Associated Non-Coding RNAs.
LF383495 - JP 2014500723-A/190998: Polycomb-Associated Non-Coding RNAs.
MA619072 - JP 2018138019-A/190998: Polycomb-Associated Non-Coding RNAs.
AB463321 - Synthetic construct DNA, clone: pF1KB9564, Homo sapiens TMEM109 gene for transmembrane protein 109, without stop codon, in Flexi system.
LF345065 - JP 2014500723-A/152568: Polycomb-Associated Non-Coding RNAs.
LF345064 - JP 2014500723-A/152567: Polycomb-Associated Non-Coding RNAs.
JD097193 - Sequence 78217 from Patent EP1572962.
JD421273 - Sequence 402297 from Patent EP1572962.
LF345063 - JP 2014500723-A/152566: Polycomb-Associated Non-Coding RNAs.
AF131803 - Homo sapiens clone 25036 mRNA sequence.
JD383486 - Sequence 364510 from Patent EP1572962.
JD389571 - Sequence 370595 from Patent EP1572962.
JD386560 - Sequence 367584 from Patent EP1572962.
JD489647 - Sequence 470671 from Patent EP1572962.
JD127289 - Sequence 108313 from Patent EP1572962.
JD290380 - Sequence 271404 from Patent EP1572962.
JD464276 - Sequence 445300 from Patent EP1572962.
JD399713 - Sequence 380737 from Patent EP1572962.
JD084301 - Sequence 65325 from Patent EP1572962.
JD418259 - Sequence 399283 from Patent EP1572962.
JD060599 - Sequence 41623 from Patent EP1572962.
JD519533 - Sequence 500557 from Patent EP1572962.
JD392252 - Sequence 373276 from Patent EP1572962.
JD133126 - Sequence 114150 from Patent EP1572962.
LF345062 - JP 2014500723-A/152565: Polycomb-Associated Non-Coding RNAs.
JD249165 - Sequence 230189 from Patent EP1572962.
JD115352 - Sequence 96376 from Patent EP1572962.
JD044700 - Sequence 25724 from Patent EP1572962.
JD387265 - Sequence 368289 from Patent EP1572962.
JD370716 - Sequence 351740 from Patent EP1572962.
JD224555 - Sequence 205579 from Patent EP1572962.
JD259946 - Sequence 240970 from Patent EP1572962.
JD370671 - Sequence 351695 from Patent EP1572962.
JD453347 - Sequence 434371 from Patent EP1572962.
JD103665 - Sequence 84689 from Patent EP1572962.
JD185799 - Sequence 166823 from Patent EP1572962.
JD338749 - Sequence 319773 from Patent EP1572962.
JD564808 - Sequence 545832 from Patent EP1572962.
MA580642 - JP 2018138019-A/152568: Polycomb-Associated Non-Coding RNAs.
MA580641 - JP 2018138019-A/152567: Polycomb-Associated Non-Coding RNAs.
MA580640 - JP 2018138019-A/152566: Polycomb-Associated Non-Coding RNAs.
MA580639 - JP 2018138019-A/152565: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_024092, NP_076997, Q9BVC6, TM109_HUMAN
UCSC ID: uc001nqg.3
RefSeq Accession: NM_024092
Protein: Q9BVC6 (aka TM109_HUMAN)
CCDS: CCDS7996.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_024092.2
exon count: 4CDS single in 3' UTR: no RNA size: 2412
ORF size: 732CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1403.50frame shift in genome: no % Coverage: 99.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.