Human Gene YTHDF2 (uc021okf.1) Description and Page Index
Description: Homo sapiens YTH domain family, member 2 (YTHDF2), transcript variant 2, mRNA. RefSeq Summary (NM_001173128): This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]. Transcript (Including UTRs) Position: hg19 chr1:29,063,133-29,096,287 Size: 33,155 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr1:29,063,633-29,095,464 Size: 31,832 Coding Exon Count: 5
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): YTHDF2 CDC HuGE Published Literature: YTHDF2 Positive Disease Associations: longevity Related Studies:
longevity Cardelli, M. et al. 2006, A Polymorphism of the YTHDF2 Gene (1p35) Located in an Alu-Rich Genomic Domain Is Associated With Human Longevity, J Gerontol A Biol Sci Med Sci 2006 61(6) 547-56.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y5A9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.