Human Gene ANXA4 (uc002sfr.4) Description and Page Index
Description: Homo sapiens annexin A4 (ANXA4), mRNA. RefSeq Summary (NM_001153): Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]. Transcript (Including UTRs) Position: hg19 chr2:69,969,127-70,053,596 Size: 84,470 Total Exon Count: 13 Strand: + Coding Region Position: hg19 chr2:70,008,698-70,052,647 Size: 43,950 Coding Exon Count: 12
ID:Q6LES2_HUMAN DESCRIPTION: RecName: Full=Annexin; Flags: Fragment; DOMAIN: A pair of annexin repeats may form one binding site for calcium and phospholipid (By similarity). SIMILARITY: Belongs to the annexin family. SIMILARITY: Contains 4 annexin repeats.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): ANXA4 CDC HuGE Published Literature: ANXA4
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6LES2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.