Human Gene ANXA4 (uc002sfr.4) Description and Page Index
  Description: Homo sapiens annexin A4 (ANXA4), mRNA.
RefSeq Summary (NM_001153): Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016].
Transcript (Including UTRs)
   Position: hg19 chr2:69,969,127-70,053,596 Size: 84,470 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg19 chr2:70,008,698-70,052,647 Size: 43,950 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr2:69,969,127-70,053,596)mRNA (may differ from genome)Protein (321 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
OMIMPubMedStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Annexin; Flags: Fragment;
DOMAIN: A pair of annexin repeats may form one binding site for calcium and phospholipid (By similarity).
SIMILARITY: Belongs to the annexin family.
SIMILARITY: Contains 4 annexin repeats.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ANXA4
CDC HuGE Published Literature: ANXA4

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 80.20 RPKM in Pancreas
Total median expression: 888.57 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -87.30227-0.385 Picture PostScript Text
3' UTR -189.43949-0.200 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001464 - Annexin
IPR018502 - Annexin_repeat
IPR018252 - Annexin_repeat_CS
IPR002391 - AnnexinIV

Pfam Domains:
PF00191 - Annexin

SCOP Domains:
47874 - Annexin

ModBase Predicted Comparative 3D Structure on Q6LES2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005544 calcium-dependent phospholipid binding

Biological Process:
GO:0007219 Notch signaling pathway

-  Descriptions from all associated GenBank mRNAs
  AB209457 - Homo sapiens mRNA for annexin IV variant protein.
BC063672 - Homo sapiens annexin A4, mRNA (cDNA clone MGC:75105 IMAGE:3908264), complete cds.
BC000182 - Homo sapiens annexin A4, mRNA (cDNA clone MGC:2271 IMAGE:3352245), complete cds.
AK293177 - Homo sapiens cDNA FLJ52218 complete cds, highly similar to Annexin A4.
BC011659 - Homo sapiens annexin A4, mRNA (cDNA clone MGC:14409 IMAGE:4301675), complete cds.
AK303960 - Homo sapiens cDNA FLJ51185 complete cds, highly similar to Annexin A4.
AK293406 - Homo sapiens cDNA FLJ52120 complete cds, highly similar to Annexin A4.
AK315511 - Homo sapiens cDNA, FLJ96576, Homo sapiens annexin A4 (ANXA4), mRNA.
AK058017 - Homo sapiens cDNA FLJ25288 fis, clone STM07104, highly similar to ANNEXIN IV.
AK293396 - Homo sapiens cDNA FLJ51794 complete cds, highly similar to Annexin A4.
FJ224287 - Homo sapiens epididymis secretory protein Li 274 (HEL-S-274) mRNA, complete cds.
M19383 - Human protein PP4-X mRNA, complete cds.
M82809 - Human annexin IV (ANX4) mRNA, complete cds.
D78152 - Homo sapiens mRNA for annexin IV (carbohydrate-binding protein p33/41), complete cds.
AY453398 - Homo sapiens proliferation-inducing protein 28 (PIG28) mRNA, complete cds.
JD321324 - Sequence 302348 from Patent EP1572962.
CU674078 - Synthetic construct Homo sapiens gateway clone IMAGE:100020663 5' read ANXA4 mRNA.
CU687798 - Synthetic construct Homo sapiens gateway clone IMAGE:100021660 5' read ANXA4 mRNA.
KJ890675 - Synthetic construct Homo sapiens clone ccsbBroadEn_00069 ANXA4 gene, encodes complete protein.
KJ901285 - Synthetic construct Homo sapiens clone ccsbBroadEn_10679 ANXA4 gene, encodes complete protein.
CR407681 - Homo sapiens full open reading frame cDNA clone RZPDo834D013D for gene ANXA4, annexin A4 complete cds, without stopcodon.
DQ896101 - Synthetic construct Homo sapiens clone IMAGE:100010561; FLH190317.01L; RZPDo839G1265D annexin A4 (ANXA4) gene, encodes complete protein.
DQ892854 - Synthetic construct clone IMAGE:100005484; FLH190321.01X; RZPDo839G1275D annexin A4 (ANXA4) gene, encodes complete protein.
BX641114 - Homo sapiens mRNA; cDNA DKFZp686H02120 (from clone DKFZp686H02120).
JD251172 - Sequence 232196 from Patent EP1572962.
JD091121 - Sequence 72145 from Patent EP1572962.
JD038725 - Sequence 19749 from Patent EP1572962.
JD554402 - Sequence 535426 from Patent EP1572962.
JD114578 - Sequence 95602 from Patent EP1572962.
JD279485 - Sequence 260509 from Patent EP1572962.
LF207256 - JP 2014500723-A/14759: Polycomb-Associated Non-Coding RNAs.
JD225733 - Sequence 206757 from Patent EP1572962.
JD292616 - Sequence 273640 from Patent EP1572962.
MA442833 - JP 2018138019-A/14759: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: hCG_39482, NM_001153, NP_001144, PIG28, Q6LES2, Q6LES2_HUMAN
UCSC ID: uc002sfr.4
RefSeq Accession: NM_001153
Protein: Q6LES2 CCDS: CCDS1894.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001153.3
exon count: 13CDS single in 3' UTR: no RNA size: 2158
ORF size: 966CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2132.00frame shift in genome: no % Coverage: 99.26
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.