Human Gene YME1L1 (uc001itj.3) Description and Page Index
Description: Homo sapiens YME1-like 1 (S. cerevisiae) (YME1L1), nuclear gene encoding mitochondrial protein, transcript variant 3, mRNA. RefSeq Summary (NM_014263): The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]. Transcript (Including UTRs) Position: hg19 chr10:27,399,040-27,443,349 Size: 44,310 Total Exon Count: 19 Strand: - Coding Region Position: hg19 chr10:27,400,906-27,443,139 Size: 42,234 Coding Exon Count: 19
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00004 - ATPase family associated with various cellular activities (AAA) PF01434 - Peptidase family M41
ModBase Predicted Comparative 3D Structure on Q96TA2-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.