Human Gene PPCS (uc001chl.3) Description and Page Index
Description: Homo sapiens phosphopantothenoylcysteine synthetase (PPCS), transcript variant 1, mRNA. RefSeq Summary (NM_024664): Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCS (EC 188.8.131.52), one of the last enzymes in this pathway, converts phosphopantothenate to phosphopantothenoylcysteine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]. Transcript (Including UTRs) Position: hg19 chr1:42,922,173-42,926,086 Size: 3,914 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chr1:42,922,237-42,925,597 Size: 3,361 Coding Exon Count: 3
ID:PPCS_HUMAN DESCRIPTION: RecName: Full=Phosphopantothenate--cysteine ligase; EC=184.108.40.206; AltName: Full=Phosphopantothenoylcysteine synthetase; Short=PPC synthetase; FUNCTION: Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. CATALYTIC ACTIVITY: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-((R)-4'-phosphopantothenoyl)-L-cysteine. PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5. SUBUNIT: Homodimer. MISCELLANEOUS: The mammalian enzyme has a preference for ATP over CTP, in contrast to the E.coli ortholog. SIMILARITY: Belongs to the PPC synthetase family. SEQUENCE CAUTION: Sequence=BAB13931.1; Type=Frameshift; Positions=282;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HAB8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.