Human Gene ZBTB43 (uc010mxf.3) Description and Page Index
  Description: Homo sapiens zinc finger and BTB domain containing 43 (ZBTB43), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr9:129,567,285-129,600,487 Size: 33,203 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr9:129,594,789-129,596,192 Size: 1,404 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr9:129,567,285-129,600,487)mRNA (may differ from genome)Protein (467 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger and BTB domain-containing protein 43; AltName: Full=Zinc finger and BTB domain-containing protein 22B; AltName: Full=Zinc finger protein 297B; AltName: Full=ZnF-x;
FUNCTION: May be involved in transcriptional regulation.
SUBUNIT: Interacts with BDP1.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 1 BTB (POZ) domain.
SIMILARITY: Contains 3 C2H2-type zinc fingers.
SEQUENCE CAUTION: Sequence=BAA24844.2; Type=Erroneous initiation;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ZBTB43
CDC HuGE Published Literature: ZBTB43

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.08 RPKM in Muscle - Skeletal
Total median expression: 187.81 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -55.30150-0.369 Picture PostScript Text
3' UTR -1318.484295-0.307 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF00651 - BTB/POZ domain

SCOP Domains:
54695 - POZ domain
57667 - C2H2 and C2HC zinc fingers

Protein Data Bank (PDB) 3-D Structure
MuPIT help


ModBase Predicted Comparative 3D Structure on O43298
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  AF049907 - Homo sapiens zinc finger transcription factor (ZNF-X) mRNA, complete cds.
AK026123 - Homo sapiens cDNA: FLJ22470 fis, clone HRC10506, highly similar to AF049907 Homo sapiens zinc finger transcription factor (ZNF-X) mRNA.
BC008828 - Homo sapiens zinc finger and BTB domain containing 43, mRNA (cDNA clone MGC:12781 IMAGE:4123095), complete cds.
AB007874 - Homo sapiens KIAA0414 mRNA.
CU679133 - Synthetic construct Homo sapiens gateway clone IMAGE:100017331 5' read ZBTB43 mRNA.
AB383876 - Synthetic construct DNA, clone: pF1KSDA0414, Homo sapiens ZBTB43 gene for zinc finger and BTB domain-containing protein 43, complete cds, without stop codon, in Flexi system.
BT007194 - Homo sapiens zinc finger protein 297B mRNA, complete cds.
KJ898444 - Synthetic construct Homo sapiens clone ccsbBroadEn_07838 ZBTB43 gene, encodes complete protein.
JD450657 - Sequence 431681 from Patent EP1572962.
JD539664 - Sequence 520688 from Patent EP1572962.
JD184507 - Sequence 165531 from Patent EP1572962.
JD341737 - Sequence 322761 from Patent EP1572962.
JD267059 - Sequence 248083 from Patent EP1572962.
JD092915 - Sequence 73939 from Patent EP1572962.
JD527963 - Sequence 508987 from Patent EP1572962.
JD426883 - Sequence 407907 from Patent EP1572962.
JD097922 - Sequence 78946 from Patent EP1572962.
JD045939 - Sequence 26963 from Patent EP1572962.
JD380137 - Sequence 361161 from Patent EP1572962.
JD040880 - Sequence 21904 from Patent EP1572962.
JD083903 - Sequence 64927 from Patent EP1572962.
JD166561 - Sequence 147585 from Patent EP1572962.
JD052817 - Sequence 33841 from Patent EP1572962.
JD319986 - Sequence 301010 from Patent EP1572962.
JD313301 - Sequence 294325 from Patent EP1572962.
JD412056 - Sequence 393080 from Patent EP1572962.
JD315544 - Sequence 296568 from Patent EP1572962.
JD410789 - Sequence 391813 from Patent EP1572962.
JD365967 - Sequence 346991 from Patent EP1572962.
JD103911 - Sequence 84935 from Patent EP1572962.
JD539412 - Sequence 520436 from Patent EP1572962.
JD175333 - Sequence 156357 from Patent EP1572962.
JD428040 - Sequence 409064 from Patent EP1572962.
JD299617 - Sequence 280641 from Patent EP1572962.
JD563818 - Sequence 544842 from Patent EP1572962.
JD443769 - Sequence 424793 from Patent EP1572962.
JD559763 - Sequence 540787 from Patent EP1572962.
JD540744 - Sequence 521768 from Patent EP1572962.
JD048379 - Sequence 29403 from Patent EP1572962.
JD076994 - Sequence 58018 from Patent EP1572962.
JD185864 - Sequence 166888 from Patent EP1572962.
JD185863 - Sequence 166887 from Patent EP1572962.
JD101923 - Sequence 82947 from Patent EP1572962.
JD101924 - Sequence 82948 from Patent EP1572962.
JD101922 - Sequence 82946 from Patent EP1572962.
JD561346 - Sequence 542370 from Patent EP1572962.
JD561347 - Sequence 542371 from Patent EP1572962.
JD481354 - Sequence 462378 from Patent EP1572962.
JD481355 - Sequence 462379 from Patent EP1572962.
JD179696 - Sequence 160720 from Patent EP1572962.
JD421962 - Sequence 402986 from Patent EP1572962.
JD341081 - Sequence 322105 from Patent EP1572962.
JD069286 - Sequence 50310 from Patent EP1572962.
JD406615 - Sequence 387639 from Patent EP1572962.
JD461011 - Sequence 442035 from Patent EP1572962.
JD139587 - Sequence 120611 from Patent EP1572962.
JD183810 - Sequence 164834 from Patent EP1572962.
JD292358 - Sequence 273382 from Patent EP1572962.
JD534379 - Sequence 515403 from Patent EP1572962.
JD364212 - Sequence 345236 from Patent EP1572962.
JD517282 - Sequence 498306 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: KIAA0414, NM_001135776, NP_054726, O43298, Q5JU96, ZBT43_HUMAN, ZBTB22B, ZNF297B
UCSC ID: uc010mxf.3
RefSeq Accession: NM_001135776
Protein: O43298 (aka ZBT43_HUMAN)
CCDS: CCDS6867.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001135776.1
exon count: 2CDS single in 3' UTR: no RNA size: 5851
ORF size: 1404CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2997.00frame shift in genome: no % Coverage: 99.97
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.