Human Gene RFX7 (uc010bfn.3) Description and Page Index
  Description: Homo sapiens regulatory factor X, 7 (RFX7), mRNA.
RefSeq Summary (NM_022841): RFX7 is a member of the regulatory factor X (RFX) family of transcription factors (see RFX1, MIM 600006) (Aftab et al., 2008 [PubMed 18673564]).[supplied by OMIM, Mar 2009]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: DRR138518.675153.1, DRR138518.479905.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr15:56,382,731-56,535,483 Size: 152,753 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr15:56,385,543-56,535,483 Size: 149,941 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:56,382,731-56,535,483)mRNA (may differ from genome)Protein (1460 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
OMIMPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: H0YLP2_HUMAN
DESCRIPTION: SubName: Full=DNA-binding protein RFX7;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.78 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 156.72 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -677.172812-0.241 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003150 - DNA-bd_RFX
IPR011991 - WHTH_trsnscrt_rep_DNA-bd

Pfam Domains:
PF02257 - RFX DNA-binding domain

SCOP Domains:
46785 - "Winged helix" DNA-binding domain

ModBase Predicted Comparative 3D Structure on H0YLP2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
  EnsemblFlyBase  
  Protein SequenceProtein Sequence  
  AlignmentAlignment  

-  Descriptions from all associated GenBank mRNAs
  LF384565 - JP 2014500723-A/192068: Polycomb-Associated Non-Coding RNAs.
MA620142 - JP 2018138019-A/192068: Polycomb-Associated Non-Coding RNAs.
AK128045 - Homo sapiens cDNA FLJ46165 fis, clone TESTI4002868, weakly similar to DNA-binding protein RFX5.
BC143438 - Homo sapiens regulatory factor X, 7, mRNA (cDNA clone IMAGE:9051946), partial cds.
AL832584 - Homo sapiens mRNA; cDNA DKFZp451H0216 (from clone DKFZp451H0216).
AL833367 - Homo sapiens mRNA; cDNA DKFZp667F0214 (from clone DKFZp667F0214).
BC112936 - Homo sapiens regulatory factor X, 7, mRNA (cDNA clone MGC:131836 IMAGE:6014850), complete cds.
AK024757 - Homo sapiens cDNA: FLJ21104 fis, clone CAS04958.
AK023056 - Homo sapiens cDNA FLJ12994 fis, clone NT2RP3000207, weakly similar to GLUCOAMYLASE S1/S2 PRECURSOR (EC 3.2.1.3).
AL834302 - Homo sapiens mRNA; cDNA DKFZp762K023 (from clone DKFZp762K023).
JD074577 - Sequence 55601 from Patent EP1572962.
JD348980 - Sequence 330004 from Patent EP1572962.
JD235495 - Sequence 216519 from Patent EP1572962.
JD091776 - Sequence 72800 from Patent EP1572962.
JD528292 - Sequence 509316 from Patent EP1572962.
JD291359 - Sequence 272383 from Patent EP1572962.
AK126103 - Homo sapiens cDNA FLJ44115 fis, clone TESTI4046819.
JD503940 - Sequence 484964 from Patent EP1572962.
JD313733 - Sequence 294757 from Patent EP1572962.
LF208551 - JP 2014500723-A/16054: Polycomb-Associated Non-Coding RNAs.
LF377643 - JP 2014500723-A/185146: Polycomb-Associated Non-Coding RNAs.
LF377641 - JP 2014500723-A/185144: Polycomb-Associated Non-Coding RNAs.
JD019486 - Sequence 510 from Patent EP1572962.
JD027357 - Sequence 8381 from Patent EP1572962.
JD021627 - Sequence 2651 from Patent EP1572962.
JD028635 - Sequence 9659 from Patent EP1572962.
JD032747 - Sequence 13771 from Patent EP1572962.
MA444128 - JP 2018138019-A/16054: Polycomb-Associated Non-Coding RNAs.
MA613220 - JP 2018138019-A/185146: Polycomb-Associated Non-Coding RNAs.
MA613218 - JP 2018138019-A/185144: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: H0YLP2, H0YLP2_HUMAN, NM_022841, NP_073752
UCSC ID: uc010bfn.3
RefSeq Accession: NM_022841
Protein: H0YLP2

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_022841.5
exon count: 9CDS single in 3' UTR: no RNA size: 7203
ORF size: 4383CDS single in intron: no Alignment % ID: 99.99
txCdsPredict score: 8963.00frame shift in genome: no % Coverage: 99.89
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 3100# strange splices: 1
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.