Human Gene MOSPD1 (uc004eyb.3) Description and Page Index
  Description: Homo sapiens motile sperm domain containing 1 (MOSPD1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chrX:134,021,662-134,049,297 Size: 27,636 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chrX:134,023,191-134,033,463 Size: 10,273 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrX:134,021,662-134,049,297)mRNA (may differ from genome)Protein (213 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Motile sperm domain-containing protein 1;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Contains 1 MSP domain.

-  MalaCards Disease Associations
  MalaCards Gene Search: MOSPD1
Diseases sorted by gene-association score: conotruncal heart malformations (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.85 RPKM in Adrenal Gland
Total median expression: 177.02 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -52.40187-0.280 Picture PostScript Text
3' UTR -367.891529-0.241 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000535 - Major_sperm
IPR008962 - PapD-like

Pfam Domains:
PF00635 - MSP (Major sperm protein) domain

SCOP Domains:
49354 - PapD-like

ModBase Predicted Comparative 3D Structure on Q9UJG1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologGenome BrowserNo ortholog
Gene Details   Gene Details 
Gene Sorter   Gene Sorter 
  Ensembl WormBase 
  Protein Sequence Protein Sequence 
  Alignment Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0030154 cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm

-  Descriptions from all associated GenBank mRNAs
  BC005700 - Homo sapiens motile sperm domain containing 1, mRNA (cDNA clone MGC:4987 IMAGE:3450155), complete cds.
AL137163 - Novel human gene mapping to chomosome X.
JD362607 - Sequence 343631 from Patent EP1572962.
JD540896 - Sequence 521920 from Patent EP1572962.
JD224336 - Sequence 205360 from Patent EP1572962.
JD046609 - Sequence 27633 from Patent EP1572962.
JD375389 - Sequence 356413 from Patent EP1572962.
JD155204 - Sequence 136228 from Patent EP1572962.
JD154028 - Sequence 135052 from Patent EP1572962.
JD239372 - Sequence 220396 from Patent EP1572962.
JD390268 - Sequence 371292 from Patent EP1572962.
JD410647 - Sequence 391671 from Patent EP1572962.
JD320461 - Sequence 301485 from Patent EP1572962.
AK299172 - Homo sapiens cDNA FLJ60824 complete cds, highly similar to Motile sperm domain-containing protein 1.
AK307196 - Homo sapiens cDNA, FLJ97144.
JD172092 - Sequence 153116 from Patent EP1572962.
JD087755 - Sequence 68779 from Patent EP1572962.
DQ323992 - Homo sapiens MOSPD1 mRNA, complete cds, alternatively spliced.
AK316570 - Homo sapiens cDNA, FLJ93634, Homo sapiens motile sperm domain containing 1 (MOSPD1), mRNA.
DQ891128 - Synthetic construct clone IMAGE:100003758; FLH169557.01X; RZPDo839D0896D motile sperm domain containing 1 (MOSPD1) gene, encodes complete protein.
DQ894307 - Synthetic construct Homo sapiens clone IMAGE:100008767; FLH169554.01L; RZPDo839D0895D motile sperm domain containing 1 (MOSPD1) gene, encodes complete protein.
AK299074 - Homo sapiens cDNA FLJ60817 complete cds, highly similar to Motile sperm domain-containing protein 1.
JD027038 - Sequence 8062 from Patent EP1572962.
JD031296 - Sequence 12320 from Patent EP1572962.
AF086333 - Homo sapiens full length insert cDNA clone ZD55A11.
JD130568 - Sequence 111592 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RE62, D3DTG5, MSPD1_HUMAN, NM_019556, NP_062456, Q5H9C5, Q5H9C7, Q9UJG1
UCSC ID: uc004eyb.3
RefSeq Accession: NM_019556
Protein: Q9UJG1 (aka MSPD1_HUMAN)
CCDS: CCDS14645.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_019556.1
exon count: 6CDS single in 3' UTR: no RNA size: 2358
ORF size: 642CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1366.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.