Human Gene ACN9 (uc003uoo.4) Description and Page Index
  Description: Homo sapiens ACN9 homolog (S. cerevisiae) (ACN9), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr7:96,745,905-96,811,075 Size: 65,171 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr7:96,747,036-96,810,527 Size: 63,492 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr7:96,745,905-96,811,075)mRNA (may differ from genome)Protein (125 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Protein ACN9 homolog, mitochondrial; Flags: Precursor;
SUBCELLULAR LOCATION: Mitochondrion (Potential).
SIMILARITY: Belongs to the ACN9 family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ACN9
CDC HuGE Published Literature: ACN9

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.90 RPKM in Testis
Total median expression: 178.68 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -399.101131-0.353 Picture PostScript Text
3' UTR -102.16548-0.186 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008381 - ACN9

Pfam Domains:
PF05347 - Complex 1 protein (LYR family)
PF13233 - Complex1_LYR-like

ModBase Predicted Comparative 3D Structure on Q9NRP4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0006105 succinate metabolic process
GO:0006111 regulation of gluconeogenesis
GO:0006979 response to oxidative stress
GO:0034553 mitochondrial respiratory chain complex II assembly

Cellular Component:
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix

-  Descriptions from all associated GenBank mRNAs
  BC028409 - Homo sapiens ACN9 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:4821924).
BC022858 - Homo sapiens ACN9 homolog (S. cerevisiae), mRNA (cDNA clone MGC:22740 IMAGE:4132451), complete cds.
AF201933 - Homo sapiens DC11 (DC11) mRNA, complete cds.
BC020621 - Homo sapiens ACN9 homolog (S. cerevisiae), mRNA (cDNA clone MGC:22236 IMAGE:4766494), complete cds.
KJ894376 - Synthetic construct Homo sapiens clone ccsbBroadEn_03770 ACN9 gene, encodes complete protein.
JD085565 - Sequence 66589 from Patent EP1572962.
JD163065 - Sequence 144089 from Patent EP1572962.
JD237732 - Sequence 218756 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A4D1J3, ACN9_HUMAN, DC11, NM_020186, NP_064571, Q75MD6, Q9NRP4
UCSC ID: uc003uoo.4
RefSeq Accession: NM_020186
Protein: Q9NRP4 (aka ACN9_HUMAN)
CCDS: CCDS5648.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_020186.2
exon count: 2CDS single in 3' UTR: no RNA size: 2068
ORF size: 378CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 467.50frame shift in genome: no % Coverage: 99.47
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.