Human Gene UHRF1BP1 (uc003oju.4) Description and Page Index
  Description: Homo sapiens UHRF1 binding protein 1 (UHRF1BP1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr6:34,759,794-34,845,291 Size: 85,498 Total Exon Count: 21 Strand: +
Coding Region
   Position: hg19 chr6:34,760,028-34,840,215 Size: 80,188 Coding Exon Count: 21 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:34,759,794-34,845,291)mRNA (may differ from genome)Protein (1440 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: URFB1_HUMAN
DESCRIPTION: RecName: Full=UHRF1-binding protein 1; AltName: Full=ICBP90-binding protein 1; AltName: Full=Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1;
FUNCTION: May act as a negative regulator of cell growth.
SUBUNIT: Homodimer (Potential). Interacts with UHRF1.
SEQUENCE CAUTION: Sequence=BAA91074.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): UHRF1BP1
CDC HuGE Published Literature: UHRF1BP1
Positive Disease Associations: Waist Circumference
Related Studies:
  1. Waist Circumference
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.65 RPKM in Testis
Total median expression: 142.09 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -146.00234-0.624 Picture PostScript Text
3' UTR -1571.265076-0.310 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026728 - UHRF1BP1_like
IPR026854 - VPS13A_N

Pfam Domains:
PF12624 - N-terminal region of Chorein or VPS13

ModBase Predicted Comparative 3D Structure on Q6BDS2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologGenome BrowserNo ortholog
Gene Details   Gene Details 
Gene Sorter   Gene Sorter 
  Ensembl WormBase 
  Protein Sequence Protein Sequence 
  Alignment Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042826 histone deacetylase binding


-  Descriptions from all associated GenBank mRNAs
  BC026164 - Homo sapiens cDNA clone IMAGE:4827604, containing frame-shift errors.
JD211401 - Sequence 192425 from Patent EP1572962.
JD462118 - Sequence 443142 from Patent EP1572962.
JD140974 - Sequence 121998 from Patent EP1572962.
BC108710 - Homo sapiens cDNA clone IMAGE:5218842.
AK000309 - Homo sapiens cDNA FLJ20302 fis, clone HEP06648.
BX640641 - Homo sapiens mRNA; cDNA DKFZp686F10110 (from clone DKFZp686F10110).
AB126777 - Homo sapiens UHRF1BP1 mRNA for ICBP90 binding protein 1, complete cds.
BC137120 - Homo sapiens UHRF1 binding protein 1, mRNA (cDNA clone MGC:168740 IMAGE:9021117), complete cds.
BC137127 - Homo sapiens UHRF1 binding protein 1, mRNA (cDNA clone MGC:168747 IMAGE:9021124), complete cds.
JD116548 - Sequence 97572 from Patent EP1572962.
JD462980 - Sequence 444004 from Patent EP1572962.
AK122918 - Homo sapiens cDNA FLJ16597 fis, clone TESTI4006247.
AK127691 - Homo sapiens cDNA FLJ45790 fis, clone NT2NE2011107.
DQ579107 - Homo sapiens piRNA piR-47219, complete sequence.
JD363624 - Sequence 344648 from Patent EP1572962.
JD360307 - Sequence 341331 from Patent EP1572962.
JD264682 - Sequence 245706 from Patent EP1572962.
JD046739 - Sequence 27763 from Patent EP1572962.
JD529063 - Sequence 510087 from Patent EP1572962.
JD104223 - Sequence 85247 from Patent EP1572962.
JD057624 - Sequence 38648 from Patent EP1572962.
JD207157 - Sequence 188181 from Patent EP1572962.
JD343032 - Sequence 324056 from Patent EP1572962.
JD426105 - Sequence 407129 from Patent EP1572962.
JD432115 - Sequence 413139 from Patent EP1572962.
JD548612 - Sequence 529636 from Patent EP1572962.
JD288515 - Sequence 269539 from Patent EP1572962.
JD053350 - Sequence 34374 from Patent EP1572962.
JD399395 - Sequence 380419 from Patent EP1572962.
JD068055 - Sequence 49079 from Patent EP1572962.
JD168786 - Sequence 149810 from Patent EP1572962.
JD349472 - Sequence 330496 from Patent EP1572962.
JD487222 - Sequence 468246 from Patent EP1572962.
JD101985 - Sequence 83009 from Patent EP1572962.
JD481429 - Sequence 462453 from Patent EP1572962.
AK001228 - Homo sapiens cDNA FLJ10366 fis, clone NT2RM2001420.
JD025210 - Sequence 6234 from Patent EP1572962.
JD028421 - Sequence 9445 from Patent EP1572962.
DQ599492 - Homo sapiens piRNA piR-37558, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: C6orf107, NM_017754, NP_060224, Q6BDS2, Q9NXE0, URFB1_HUMAN
UCSC ID: uc003oju.4
RefSeq Accession: NM_017754
Protein: Q6BDS2 (aka URFB1_HUMAN)
CCDS: CCDS43455.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_017754.3
exon count: 21CDS single in 3' UTR: no RNA size: 9658
ORF size: 4323CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 6621.00frame shift in genome: no % Coverage: 99.74
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.