ID:UBP38_HUMAN DESCRIPTION: RecName: Full=Ubiquitin carboxyl-terminal hydrolase 38; EC=18.104.22.168; AltName: Full=Deubiquitinating enzyme 38; AltName: Full=HP43.8KD; AltName: Full=Ubiquitin thioesterase 38; AltName: Full=Ubiquitin-specific-processing protease 38; FUNCTION: Deubiquitinating enzyme exhibiting a preference towards 'Lys-63'-linked Ubiquitin chains. CATALYTIC ACTIVITY: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). TISSUE SPECIFICITY: Highly expressed in skeletal muscle. Expressed in adrenal gland. SIMILARITY: Belongs to the peptidase C19 family. SEQUENCE CAUTION: Sequence=AAK26248.1; Type=Erroneous initiation; Sequence=BAB71627.1; Type=Erroneous initiation; Sequence=BAC03730.1; Type=Miscellaneous discrepancy; Note=The absence of the residues from Tyr-840 to Ser-871 is not the result of an alternative splicing;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): USP38 CDC HuGE Published Literature: USP38 Positive Disease Associations: Iron Related Studies:
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NB14
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.