Human Gene MINA (uc003dsb.1) Description and Page Index
  Description: Homo sapiens MYC induced nuclear antigen (MINA), transcript variant 2, mRNA.
RefSeq Summary (NM_153182): MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008].
Transcript (Including UTRs)
   Position: hg19 chr3:97,660,661-97,691,295 Size: 30,635 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr3:97,664,028-97,686,437 Size: 22,410 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr3:97,660,661-97,691,295)mRNA (may differ from genome)Protein (465 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=MYC-induced nuclear antigen; AltName: Full=Mineral dust-induced gene protein; AltName: Full=Nucleolar protein 52;
FUNCTION: Involved in cellular proliferation. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.
SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus.
TISSUE SPECIFICITY: Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines.
INDUCTION: Up-regulated in response to MYC, in alveolar macrophages from coal miners and in silica particle-treated A549 lung cancer cells.
SIMILARITY: Belongs to the MINA53/NO66 family.
SIMILARITY: Contains 1 JmjC domain.
SEQUENCE CAUTION: Sequence=CAH10679.1; Type=Erroneous termination; Positions=431; Note=Translated as Trp;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.11 RPKM in Thyroid
Total median expression: 204.48 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -43.60110-0.396 Picture PostScript Text
3' UTR -856.843367-0.254 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003347 - JmjC_dom
IPR013109 - NO66/MINA
IPR014710 - RmlC-like_jellyroll

Pfam Domains:
PF08007 - Cupin superfamily protein

SCOP Domains:
51182 - RmlC-like cupins
51197 - Clavaminate synthase-like
51215 - Regulatory protein AraC

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q8IUF8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0016491 oxidoreductase activity
GO:0032452 histone demethylase activity
GO:0032453 histone demethylase activity (H3-K4 specific)
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
GO:0051864 histone demethylase activity (H3-K36 specific)

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016577 histone demethylation
GO:0030961 peptidyl-arginine hydroxylation
GO:0034720 histone H3-K4 demethylation
GO:0042254 ribosome biogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0055114 oxidation-reduction process
GO:0070544 histone H3-K36 demethylation

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005730 nucleolus
GO:0005829 cytosol

-  Descriptions from all associated GenBank mRNAs
  CR627479 - Homo sapiens mRNA; cDNA DKFZp762O1912 (from clone DKFZp762O1912).
AY302110 - Homo sapiens MDIG (MDIG) mRNA, complete cds; alternatively spliced.
DQ453796 - Homo sapiens MYC induced nuclear antigen (MINA) mRNA, complete cds.
AB083189 - Homo sapiens mRNA for Mina53, complete cds.
AB083190 - Homo sapiens mRNA for Mina53 form-2, complete cds.
JD349687 - Sequence 330711 from Patent EP1572962.
AK027299 - Homo sapiens cDNA FLJ14393 fis, clone HEMBA1003222.
AY390536 - Homo sapiens NO52 protein (NO52) mRNA, complete cds.
BC014928 - Homo sapiens MYC induced nuclear antigen, mRNA (cDNA clone MGC:17935 IMAGE:3916148), complete cds.
AY456380 - Homo sapiens mineral dust induced gene protein 2 (MDIG) mRNA, complete cds, alternatively spliced.
JD285932 - Sequence 266956 from Patent EP1572962.
KJ901079 - Synthetic construct Homo sapiens clone ccsbBroadEn_10473 MINA gene, encodes complete protein.
AB083191 - Homo sapiens mRNA for Mina53 form-3, complete cds.
AB083193 - Homo sapiens mRNA for Mina53, partial cds, clone:5'-RACE-b.
AB083192 - Homo sapiens mRNA for Mina53, partial cds, clone:5'-RACE-a.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8IUF8 (Reactome details) participates in the following event(s):

R-HSA-4724279 KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3
R-HSA-5661120 KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3
R-HSA-3214842 HDMs demethylate histones
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-4839726 Chromatin organization

-  Other Names for This Gene
  Alternate Gene Symbols: D3DN35, MDIG, MINA53, MINA_HUMAN, NM_153182, NO52, NP_694822, Q6AHW4, Q6SKS0, Q8IU69, Q8IUF6, Q8IUF7, Q8IUF8, Q96C17, Q96KB0
UCSC ID: uc003dsb.1
RefSeq Accession: NM_153182
Protein: Q8IUF8 (aka MINA_HUMAN)
CCDS: CCDS2929.1, CCDS43114.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_153182.3
exon count: 10CDS single in 3' UTR: no RNA size: 4875
ORF size: 1398CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2996.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.