Human Gene MINA (uc003dsb.1) Description and Page Index
Description: Homo sapiens MYC induced nuclear antigen (MINA), transcript variant 2, mRNA. RefSeq Summary (NM_153182): MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]. Transcript (Including UTRs) Position: hg19 chr3:97,660,661-97,691,295 Size: 30,635 Total Exon Count: 10 Strand: - Coding Region Position: hg19 chr3:97,664,028-97,686,437 Size: 22,410 Coding Exon Count: 9
ID:MINA_HUMAN DESCRIPTION: RecName: Full=MYC-induced nuclear antigen; AltName: Full=Mineral dust-induced gene protein; AltName: Full=Nucleolar protein 52; FUNCTION: Involved in cellular proliferation. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. TISSUE SPECIFICITY: Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines. INDUCTION: Up-regulated in response to MYC, in alveolar macrophages from coal miners and in silica particle-treated A549 lung cancer cells. SIMILARITY: Belongs to the MINA53/NO66 family. SIMILARITY: Contains 1 JmjC domain. SEQUENCE CAUTION: Sequence=CAH10679.1; Type=Erroneous termination; Positions=431; Note=Translated as Trp;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IUF8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.