Human Gene METTL2A (uc002izv.2) Description and Page Index
  Description: Homo sapiens methyltransferase like 2A (METTL2A), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr17:60,501,246-60,527,454 Size: 26,209 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr17:60,501,264-60,526,090 Size: 24,827 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr17:60,501,246-60,527,454)mRNA (may differ from genome)Protein (378 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtPubMedStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Methyltransferase-like protein 2A; EC=2.1.1.-;
FUNCTION: Probable methyltransferase (By similarity).
SIMILARITY: Belongs to the methyltransferase superfamily. METL family.
SEQUENCE CAUTION: Sequence=BAB14260.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.01 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 185.69 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -3.7018-0.206 Picture PostScript Text
3' UTR -442.641364-0.325 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026113 - MeTrfase
IPR017280 - MeTrfase_METTL2_prd

Pfam Domains:
PF01209 - ubiE/COQ5 methyltransferase family
PF08241 - Methyltransferase domain
PF08242 - Methyltransferase domain
PF13489 - Methyltransferase domain
PF13649 - Methyltransferase domain
PF13847 - Methyltransferase domain

SCOP Domains:
53335 - S-adenosyl-L-methionine-dependent methyltransferases

ModBase Predicted Comparative 3D Structure on Q96IZ6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene Details   Gene Details 
Gene Sorter   Gene Sorter 
    Protein Sequence 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008168 methyltransferase activity
GO:0016427 tRNA (cytosine) methyltransferase activity
GO:0016740 transferase activity

Biological Process:
GO:0030488 tRNA methylation
GO:0032259 methylation

-  Descriptions from all associated GenBank mRNAs
  BC006985 - Homo sapiens methyltransferase like 2A, mRNA (cDNA clone MGC:12209 IMAGE:3930328), complete cds.
AB590991 - Synthetic construct DNA, clone: pFN21AE1857, Homo sapiens METTL2A gene for methyltransferase like 2A, without stop codon, in Flexi system.
JD395176 - Sequence 376200 from Patent EP1572962.
JD395177 - Sequence 376201 from Patent EP1572962.
AF161384 - Homo sapiens HSPC266 mRNA, partial cds.
AK022822 - Homo sapiens cDNA FLJ12760 fis, clone NT2RP2001366.
AF161385 - Homo sapiens HSPC267 mRNA, partial cds.
JD332144 - Sequence 313168 from Patent EP1572962.
JD139370 - Sequence 120394 from Patent EP1572962.
JF432470 - Synthetic construct Homo sapiens clone IMAGE:100073691 methyltransferase like 2A (METTL2A) gene, encodes complete protein.
KJ904190 - Synthetic construct Homo sapiens clone ccsbBroadEn_13584 METTL2A gene, encodes complete protein.
AK000991 - Homo sapiens cDNA FLJ10129 fis, clone HEMBA1003033, highly similar to Methyltransferase-like protein 2 (EC 2.1.1.-).
JD335977 - Sequence 317001 from Patent EP1572962.
JD364809 - Sequence 345833 from Patent EP1572962.
JD546275 - Sequence 527299 from Patent EP1572962.
JD221877 - Sequence 202901 from Patent EP1572962.
JD455061 - Sequence 436085 from Patent EP1572962.
JD537302 - Sequence 518326 from Patent EP1572962.
JD194649 - Sequence 175673 from Patent EP1572962.
JD135702 - Sequence 116726 from Patent EP1572962.
JD238288 - Sequence 219312 from Patent EP1572962.
JD324495 - Sequence 305519 from Patent EP1572962.
JD180020 - Sequence 161044 from Patent EP1572962.
JD380242 - Sequence 361266 from Patent EP1572962.
DQ598947 - Homo sapiens piRNA piR-37013, complete sequence.
JD359313 - Sequence 340337 from Patent EP1572962.
JD564242 - Sequence 545266 from Patent EP1572962.
JD537067 - Sequence 518091 from Patent EP1572962.
JD257030 - Sequence 238054 from Patent EP1572962.
JD514937 - Sequence 495961 from Patent EP1572962.
JD472424 - Sequence 453448 from Patent EP1572962.
JD421484 - Sequence 402508 from Patent EP1572962.
JD179105 - Sequence 160129 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NNC4, HSPC266, MET2A_HUMAN, METTL2, NM_181725, NP_859076, Q96IZ6, Q9H9G9, Q9NUI8, Q9P0B5
UCSC ID: uc002izv.2
RefSeq Accession: NM_181725
Protein: Q96IZ6 (aka MET2A_HUMAN)
CCDS: CCDS45752.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_181725.3
exon count: 9CDS single in 3' UTR: no RNA size: 2519
ORF size: 1137CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2474.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.