Human Gene FAM133B (uc003umc.3) Description and Page Index
  Description: Homo sapiens family with sequence similarity 133, member B (FAM133B), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr7:92,190,072-92,219,706 Size: 29,635 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr7:92,191,596-92,219,605 Size: 28,010 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr7:92,190,072-92,219,706)mRNA (may differ from genome)Protein (247 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Protein FAM133B;
SIMILARITY: Belongs to the FAM133 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.95 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 228.94 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -46.50101-0.460 Picture PostScript Text
3' UTR -404.951524-0.266 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026766 - Fam133

ModBase Predicted Comparative 3D Structure on Q5BKY9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding

-  Descriptions from all associated GenBank mRNAs
  JD097960 - Sequence 78984 from Patent EP1572962.
BC032461 - Homo sapiens family with sequence similarity 133, member B, mRNA (cDNA clone MGC:40405 IMAGE:5197918), complete cds.
BC057771 - Homo sapiens family with sequence similarity 133, member B, mRNA (cDNA clone MGC:71532 IMAGE:5301001), complete cds.
AL833918 - Homo sapiens mRNA; cDNA DKFZp564O052 (from clone DKFZp564O052).
BC090868 - Homo sapiens family with sequence similarity 133, member B, mRNA (cDNA clone MGC:102872 IMAGE:6190536), complete cds.
BC073952 - Homo sapiens family with sequence similarity 133, member B, mRNA (cDNA clone IMAGE:5577230), with apparent retained intron.
AK125498 - Homo sapiens cDNA FLJ43509 fis, clone PERIC2003699.
JD247481 - Sequence 228505 from Patent EP1572962.
JD363511 - Sequence 344535 from Patent EP1572962.
JD531143 - Sequence 512167 from Patent EP1572962.
JD248896 - Sequence 229920 from Patent EP1572962.
JD383189 - Sequence 364213 from Patent EP1572962.
JD368647 - Sequence 349671 from Patent EP1572962.
JD555832 - Sequence 536856 from Patent EP1572962.
JD555833 - Sequence 536857 from Patent EP1572962.
JD314297 - Sequence 295321 from Patent EP1572962.
JD133936 - Sequence 114960 from Patent EP1572962.
AK313692 - Homo sapiens cDNA, FLJ94282.
AB528131 - Synthetic construct DNA, clone: pF1KE0446, Homo sapiens FAM133B gene for family with sequence similarity 133, member B, without stop codon, in Flexi system.
AM392992 - Synthetic construct Homo sapiens clone IMAGE:100001930 for hypothetical protein (MGC40405 gene).
AM393866 - Synthetic construct Homo sapiens clone IMAGE:100001935 for hypothetical protein (MGC40405 gene).
BC062706 - Homo sapiens family with sequence similarity 133, member B, mRNA (cDNA clone IMAGE:4686277), partial cds.
BC017874 - Homo sapiens family with sequence similarity 133, member B, mRNA (cDNA clone IMAGE:4697504), partial cds.
JD170836 - Sequence 151860 from Patent EP1572962.
BC079834 - Homo sapiens cDNA clone IMAGE:6212309, **** WARNING: chimeric clone ****.
JD358628 - Sequence 339652 from Patent EP1572962.
JD528689 - Sequence 509713 from Patent EP1572962.
JD486813 - Sequence 467837 from Patent EP1572962.
JD362211 - Sequence 343235 from Patent EP1572962.
JD320627 - Sequence 301651 from Patent EP1572962.
JD162468 - Sequence 143492 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2R994, F133B_HUMAN, NM_152789, NP_001035146, Q05D67, Q5BKY9, Q6P5S6, Q8N0W8
UCSC ID: uc003umc.3
RefSeq Accession: NM_152789
Protein: Q5BKY9 (aka F133B_HUMAN)
CCDS: CCDS47640.1, CCDS47641.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_152789.2
exon count: 11CDS single in 3' UTR: no RNA size: 2369
ORF size: 744CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1688.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.