Description: Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 10 (ABCC10), transcript variant MRP7, mRNA. RefSeq Summary (NM_001198934): The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010]. Transcript (Including UTRs) Position: hg19 chr6:43,395,292-43,418,163 Size: 22,872 Total Exon Count: 22 Strand: + Coding Region Position: hg19 chr6:43,395,717-43,417,829 Size: 22,113 Coding Exon Count: 21
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5T3U5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK000002 - Homo sapiens FLJ00002 mRNA for FLJ00002 protein. JD211372 - Sequence 192396 from Patent EP1572962. AB384411 - Synthetic construct DNA, clone: pF1KSDF0002, Homo sapiens ABCC10 gene for ATP-binding cassette, sub-family C member 10, complete cds, without stop codon, in Flexi system. AY032599 - Homo sapiens multidrug resistance-associated protein 7 (SIMRP7) mRNA, complete cds. BC166699 - Synthetic construct Homo sapiens clone IMAGE:100066425, MGC:195562 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 (ABCC10) mRNA, encodes complete protein. AK024446 - Homo sapiens mRNA for FLJ00036 protein, partial cds. JD128407 - Sequence 109431 from Patent EP1572962. AL133613 - Homo sapiens mRNA; cDNA DKFZp434L0827 (from clone DKFZp434L0827); partial cds. JD122265 - Sequence 103289 from Patent EP1572962. JD316583 - Sequence 297607 from Patent EP1572962. JD473010 - Sequence 454034 from Patent EP1572962. JD209569 - Sequence 190593 from Patent EP1572962. JD148882 - Sequence 129906 from Patent EP1572962. U66684 - Homo sapiens clone EST182763 mRNA sequence. JD438133 - Sequence 419157 from Patent EP1572962. JD477009 - Sequence 458033 from Patent EP1572962. BC024103 - Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 10, mRNA (cDNA clone IMAGE:4554918), complete cds. AL122095 - Homo sapiens mRNA; cDNA DKFZp434I2115 (from clone DKFZp434I2115). JD562255 - Sequence 543279 from Patent EP1572962. JD123824 - Sequence 104848 from Patent EP1572962. JD209069 - Sequence 190093 from Patent EP1572962. JD376939 - Sequence 357963 from Patent EP1572962. JD358359 - Sequence 339383 from Patent EP1572962. JD254398 - Sequence 235422 from Patent EP1572962. JD411652 - Sequence 392676 from Patent EP1572962. JD521787 - Sequence 502811 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa02010 - ABC transporters
Reactome (by CSHL, EBI, and GO)
Protein Q5T3U5 (Reactome details) participates in the following event(s):
R-HSA-1454916 The ABCC family mediates organic anion transport R-HSA-382556 ABC-family proteins mediated transport R-HSA-382551 Transport of small molecules