Human Gene ZNF528 (uc002pzh.3) Description and Page Index
  Description: Homo sapiens zinc finger protein 528 (ZNF528), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:52,901,121-52,921,657 Size: 20,537 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr19:52,905,267-52,919,992 Size: 14,726 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:52,901,121-52,921,657)mRNA (may differ from genome)Protein (628 aa)
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OMIMPubMedReactomeStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ZN528_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 528;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 15 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.
SEQUENCE CAUTION: Sequence=BAB47456.1; Type=Erroneous initiation;

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.56 RPKM in Brain - Cerebellum
Total median expression: 208.44 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -116.11426-0.273 Picture PostScript Text
3' UTR -502.281665-0.302 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box, Pfam 01352)
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q3MIS6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK056552 - Homo sapiens cDNA FLJ31990 fis, clone NT2RP7009019, highly similar to Homo sapiens zinc finger protein 528 (ZNF528), mRNA.
AL833325 - Homo sapiens mRNA; cDNA DKFZp686C2433 (from clone DKFZp686C2433).
JD440007 - Sequence 421031 from Patent EP1572962.
JD302089 - Sequence 283113 from Patent EP1572962.
JD355805 - Sequence 336829 from Patent EP1572962.
JD048463 - Sequence 29487 from Patent EP1572962.
BC101712 - Homo sapiens zinc finger protein 528, mRNA (cDNA clone MGC:126761 IMAGE:8069218), complete cds.
BC111950 - Homo sapiens zinc finger protein 528, mRNA (cDNA clone MGC:138155 IMAGE:8327418), complete cds.
JD436625 - Sequence 417649 from Patent EP1572962.
JD067204 - Sequence 48228 from Patent EP1572962.
JD095814 - Sequence 76838 from Patent EP1572962.
EU446540 - Synthetic construct Homo sapiens clone IMAGE:100069975; IMAGE:100011749; FLH257082.01L zinc finger protein 528 (ZNF528) gene, encodes complete protein.
BX640670 - Homo sapiens mRNA; cDNA DKFZp686N0597 (from clone DKFZp686N0597).
AL832630 - Homo sapiens mRNA; cDNA DKFZp451E1618 (from clone DKFZp451E1618); complete cds.
AB058730 - Homo sapiens mRNA for KIAA1827 protein, partial cds.
JD507138 - Sequence 488162 from Patent EP1572962.
JD314882 - Sequence 295906 from Patent EP1572962.
JD507138 - Sequence 488162 from Patent EP1572962.
JD314882 - Sequence 295906 from Patent EP1572962.
JD314879 - Sequence 295903 from Patent EP1572962.
JD314877 - Sequence 295901 from Patent EP1572962.
JD314878 - Sequence 295902 from Patent EP1572962.
JD330516 - Sequence 311540 from Patent EP1572962.
JD066994 - Sequence 48018 from Patent EP1572962.
DQ598852 - Homo sapiens piRNA piR-36918, complete sequence.
JD314882 - Sequence 295906 from Patent EP1572962.
AK023429 - Homo sapiens cDNA FLJ13367 fis, clone PLACE1000583, weakly similar to ZINC FINGER PROTEIN 83.
JD098222 - Sequence 79246 from Patent EP1572962.
JD368254 - Sequence 349278 from Patent EP1572962.
JD286197 - Sequence 267221 from Patent EP1572962.
JD276691 - Sequence 257715 from Patent EP1572962.
JD109274 - Sequence 90298 from Patent EP1572962.
JD180398 - Sequence 161422 from Patent EP1572962.
JD488979 - Sequence 470003 from Patent EP1572962.
JD300857 - Sequence 281881 from Patent EP1572962.
JD293428 - Sequence 274452 from Patent EP1572962.
JD383938 - Sequence 364962 from Patent EP1572962.
JD556804 - Sequence 537828 from Patent EP1572962.
JD262134 - Sequence 243158 from Patent EP1572962.
JD165286 - Sequence 146310 from Patent EP1572962.
JD560995 - Sequence 542019 from Patent EP1572962.
JD213300 - Sequence 194324 from Patent EP1572962.
JD463224 - Sequence 444248 from Patent EP1572962.
JD413796 - Sequence 394820 from Patent EP1572962.
JD255754 - Sequence 236778 from Patent EP1572962.
JD070350 - Sequence 51374 from Patent EP1572962.
JD552354 - Sequence 533378 from Patent EP1572962.
JD285782 - Sequence 266806 from Patent EP1572962.
JD075010 - Sequence 56034 from Patent EP1572962.
JD254600 - Sequence 235624 from Patent EP1572962.
JD133890 - Sequence 114914 from Patent EP1572962.
JD505217 - Sequence 486241 from Patent EP1572962.
JD563424 - Sequence 544448 from Patent EP1572962.
JD523172 - Sequence 504196 from Patent EP1572962.
JD457851 - Sequence 438875 from Patent EP1572962.
JD394321 - Sequence 375345 from Patent EP1572962.
JD403493 - Sequence 384517 from Patent EP1572962.
JD295729 - Sequence 276753 from Patent EP1572962.
JD070003 - Sequence 51027 from Patent EP1572962.
JD345675 - Sequence 326699 from Patent EP1572962.
JD207669 - Sequence 188693 from Patent EP1572962.
JD316322 - Sequence 297346 from Patent EP1572962.
JD368090 - Sequence 349114 from Patent EP1572962.
JD515204 - Sequence 496228 from Patent EP1572962.
JD514212 - Sequence 495236 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q3MIS6 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: B3KPN4, KIAA1827, NM_032423, NP_115799, Q3MIS6, Q86T88, Q96JK0, ZN528_HUMAN
UCSC ID: uc002pzh.3
RefSeq Accession: NM_032423
Protein: Q3MIS6 (aka ZN528_HUMAN)
CCDS: CCDS33091.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_032423.2
exon count: 7CDS single in 3' UTR: no RNA size: 3995
ORF size: 1887CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3775.00frame shift in genome: no % Coverage: 99.57
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.