Human Gene CCNB3 (uc004doy.3) Description and Page Index
  Description: Homo sapiens cyclin B3 (CCNB3), transcript variant 3, mRNA.
RefSeq Summary (NM_033031): The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as positive regulators of cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle. Different cyclins exhibit distinct expression and degradation patterns, which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chicken and drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and may be required for proper spindle reorganization and restoration of the interphase nucleus. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK292454.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on expression ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chrX:50,027,542-50,094,911 Size: 67,370 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg19 chrX:50,028,164-50,094,702 Size: 66,539 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:50,027,542-50,094,911)mRNA (may differ from genome)Protein (1395 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: CCNB3_HUMAN
DESCRIPTION: RecName: Full=G2/mitotic-specific cyclin-B3;
FUNCTION: Cyclins are positive regulatory subunits of the cyclin- dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I.
SUBUNIT: Interacts with CDK2 kinase.
INTERACTION: A8UKE6:CDK2 (xeno); NbExp=2; IntAct=EBI-767764, EBI-767796;
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Testis specific. In testis, it is expressed in developing germ cells, but not in Leydig cells. Weakly or not expressed in other tissues.
DOMAIN: The N-terminal destruction box (D-box) probably acts as a recognition signal for degradation via the ubiquitin-proteasome pathway (By similarity).
PTM: Ubiquitinated (Probable). Ubiquitination leads to its degradation during anaphase entry, after degradation of CCNB1.
SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.

-  MalaCards Disease Associations
  MalaCards Gene Search: CCNB3
Diseases sorted by gene-association score: ewing sarcoma (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.38 RPKM in Testis
Total median expression: 12.13 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -21.74112-0.194 Picture PostScript Text
3' UTR -28.30209-0.135 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013763 - Cyclin-like
IPR015452 - Cyclin_B3
IPR004367 - Cyclin_C
IPR006671 - Cyclin_N

Pfam Domains:
PF00134 - Cyclin, N-terminal domain
PF02984 - Cyclin, C-terminal domain

SCOP Domains:
47954 - Cyclin-like

ModBase Predicted Comparative 3D Structure on Q8WWL7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene Details   Gene Details 
Gene Sorter   Gene Sorter 
    WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0019901 protein kinase binding

Biological Process:
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0007049 cell cycle
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0051301 cell division
GO:0051321 meiotic cell cycle

Cellular Component:
GO:0005634 nucleus
GO:0016607 nuclear speck


-  Descriptions from all associated GenBank mRNAs
  AK292454 - Homo sapiens cDNA FLJ77187 complete cds, highly similar to Homo sapiens cyclin B3 (CCNB3), transcript variant 3, mRNA.
AJ314764 - Homo sapiens mRNA for cyclin B3 (CCNB3 gene).
AJ314765 - Homo sapiens mRNA for cyclin B3 isoform 1 (CCNB3 gene).
AJ314766 - Homo sapiens mRNA for cyclin B3 isoform 2 (CCNB3 gene).
AJ416458 - Homo sapiens mRNA for cyclin B3 (CCNB3 gene).
BC172237 - Synthetic construct Homo sapiens clone IMAGE:100068931, MGC:198942 cyclin B3 (CCNB3) mRNA, encodes complete protein.
BC172544 - Synthetic construct Homo sapiens clone IMAGE:100069238, MGC:199249 cyclin B3 (CCNB3) mRNA, encodes complete protein.
AJ421672 - Homo sapiens partial mRNA for cyclin B3 (CCNB3 gene), variant A.
AJ421673 - Homo sapiens partial mRNA for cyclin B3 (CCNB3 gene), variant B.
AJ421674 - Homo sapiens partial mRNA for cyclin B3 (CCNB3 gene), variant C.
JD561566 - Sequence 542590 from Patent EP1572962.
JD204183 - Sequence 185207 from Patent EP1572962.
AY927611 - Homo sapiens mRNA sequence.
JD499002 - Sequence 480026 from Patent EP1572962.
JD096871 - Sequence 77895 from Patent EP1572962.
JD370877 - Sequence 351901 from Patent EP1572962.
AL137550 - Homo sapiens mRNA; cDNA DKFZp434C0820 (from clone DKFZp434C0820).
JD251221 - Sequence 232245 from Patent EP1572962.
JD197282 - Sequence 178306 from Patent EP1572962.
JD145997 - Sequence 127021 from Patent EP1572962.
JD175150 - Sequence 156174 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04110 - Cell cycle
hsa04115 - p53 signaling pathway
hsa04914 - Progesterone-mediated oocyte maturation

-  Other Names for This Gene
  Alternate Gene Symbols: B1AQI5, B1AQI6, CCNB3_HUMAN, CYCB3, NM_033031, NP_149020, Q8WWL7, Q96SB5, Q96SB6, Q96SB7, Q9NT38
UCSC ID: uc004doy.3
RefSeq Accession: NM_033031
Protein: Q8WWL7 (aka CCNB3_HUMAN or CGB3_HUMAN)
CCDS: CCDS14331.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_033031.2
exon count: 12CDS single in 3' UTR: no RNA size: 4524
ORF size: 4188CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 6899.00frame shift in genome: no % Coverage: 99.67
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.