Human Gene SPDYE1 (uc003tjf.3) Description and Page Index
Description: Homo sapiens speedy/RINGO cell cycle regulator family member E1 (SPDYE1), mRNA. RefSeq Summary (NM_175064): This gene is located at chromosome 7p13 which is close to the Williams Beuren syndrome chromosome region 7q11.23. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AF412027.1, AL137266.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on expression ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr7:44,040,489-44,049,723 Size: 9,235 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chr7:44,040,625-44,047,367 Size: 6,743 Coding Exon Count: 6
ID:SPDE1_HUMAN DESCRIPTION: RecName: Full=Speedy protein E1; AltName: Full=Williams-Beuren syndrome chromosomal region 19 protein; DISEASE: Note=SPDYE1 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. SIMILARITY: Belongs to the Speedy/Ringo family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF11357 - Cell cycle regulatory protein
ModBase Predicted Comparative 3D Structure on Q8NFV5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.