Human Gene TAS1R1 (uc001ant.3) Description and Page Index
  Description: Homo sapiens taste receptor, type 1, member 1 (TAS1R1), transcript variant 2, mRNA.
RefSeq Summary (NM_138697): The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
Transcript (Including UTRs)
   Position: hg19 chr1:6,615,338-6,639,817 Size: 24,480 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr1:6,615,434-6,639,644 Size: 24,211 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:6,615,338-6,639,817)mRNA (may differ from genome)Protein (841 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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OMIMPubMedReactomeStanford SOURCETreefamUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: TS1R1_HUMAN
DESCRIPTION: RecName: Full=Taste receptor type 1 member 1; AltName: Full=G-protein coupled receptor 70; Flags: Precursor;
FUNCTION: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.
SUBUNIT: Forms heterodimers with TAS1R3.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
SEQUENCE CAUTION: Sequence=AAL91359.1; Type=Erroneous initiation; Sequence=AAL91360.1; Type=Erroneous initiation; Sequence=AAL91361.1; Type=Erroneous initiation; Sequence=BAC05845.1; Type=Erroneous gene model prediction;
WEB RESOURCE: Name=Protein Spotlight; Note=The taste experience - Issue 55 of February 2005; URL="http://web.expasy.org/spotlight/back_issues/sptlt055.shtml";

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TAS1R1
CDC HuGE Published Literature: TAS1R1
Positive Disease Associations: Basophils
Related Studies:
  1. Basophils
    Yukinori Okada et al. PLoS genetics 2011, Identification of nine novel loci associated with white blood cell subtypes in a Japanese population., PLoS genetics. [PubMed 21738478]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.46 RPKM in Testis
Total median expression: 9.34 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -34.7096-0.361 Picture PostScript Text
3' UTR -71.30173-0.412 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001828 - ANF_lig-bd_rcpt
IPR000337 - GPCR_3
IPR011500 - GPCR_3_9-Cys_dom
IPR017978 - GPCR_3_C
IPR017979 - GPCR_3_CS

Pfam Domains:
PF00003 - 7 transmembrane sweet-taste receptor of 3 GCPR
PF01094 - Receptor family ligand binding region
PF07562 - Nine Cysteines Domain of family 3 GPCR
PF13458 - Periplasmic binding protein

SCOP Domains:
53822 - Periplasmic binding protein-like I
57586 - TNF receptor-like

ModBase Predicted Comparative 3D Structure on Q7RTX1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0008527 taste receptor activity
GO:0046982 protein heterodimerization activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0050896 response to stimulus
GO:0050909 sensory perception of taste
GO:0050917 sensory perception of umami taste

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC136515 - Homo sapiens taste receptor, type 1, member 1, mRNA (cDNA clone MGC:168128 IMAGE:9020505), complete cds.
BC136516 - Homo sapiens taste receptor, type 1, member 1, mRNA (cDNA clone MGC:168129 IMAGE:9020506), complete cds.
AK315805 - Homo sapiens cDNA, FLJ96929, highly similar to Homo sapiens taste receptor, type 1, member 1 (TAS1R1), mRNA.
AK292014 - Homo sapiens cDNA FLJ77460 complete cds, highly similar to Homo sapiens taste receptor, type 1, member 1 (TAS1R1), transcript variant 3, mRNA.
AK293499 - Homo sapiens cDNA FLJ52254 complete cds, highly similar to Homo sapiens taste receptor, type 1, member 1 (TAS1R1), transcript variant 3, mRNA.
AF387618 - Homo sapiens gm148 form B mRNA, complete cds, alternatively spliced.
AF387617 - Homo sapiens gm148 form A mRNA, complete cds, alternatively spliced.
AF387619 - Homo sapiens gm148 form C mRNA, partial cds, alternatively spliced.
AF387620 - Homo sapiens gm148 form D mRNA, partial cds, alternatively spliced.
DQ592253 - Homo sapiens piRNA piR-59365, complete sequence.
JD182763 - Sequence 163787 from Patent EP1572962.
JD279242 - Sequence 260266 from Patent EP1572962.
JD554767 - Sequence 535791 from Patent EP1572962.
JD180944 - Sequence 161968 from Patent EP1572962.
JD426036 - Sequence 407060 from Patent EP1572962.
JD411119 - Sequence 392143 from Patent EP1572962.
JD254260 - Sequence 235284 from Patent EP1572962.
JD219206 - Sequence 200230 from Patent EP1572962.
JD075277 - Sequence 56301 from Patent EP1572962.
JD162932 - Sequence 143956 from Patent EP1572962.
JD257835 - Sequence 238859 from Patent EP1572962.
JD046289 - Sequence 27313 from Patent EP1572962.
JD046290 - Sequence 27314 from Patent EP1572962.
JD090542 - Sequence 71566 from Patent EP1572962.
JD268044 - Sequence 249068 from Patent EP1572962.
JD081458 - Sequence 62482 from Patent EP1572962.
JD382260 - Sequence 363284 from Patent EP1572962.
JD100257 - Sequence 81281 from Patent EP1572962.
JD056793 - Sequence 37817 from Patent EP1572962.
JD056794 - Sequence 37818 from Patent EP1572962.
JD138900 - Sequence 119924 from Patent EP1572962.
JD138901 - Sequence 119925 from Patent EP1572962.
JD385290 - Sequence 366314 from Patent EP1572962.
JD489953 - Sequence 470977 from Patent EP1572962.
JD204991 - Sequence 186015 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04742 - Taste transduction

Reactome (by CSHL, EBI, and GO)

Protein Q7RTX1 (Reactome details) participates in the following event(s):

R-HSA-444705 T1R1/T1R3 dimer is the umami taste receptor
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
R-HSA-418594 G alpha (i) signalling events
R-HSA-500792 GPCR ligand binding
R-HSA-388396 GPCR downstream signalling
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B2RMX0, GM148, GPR70, NM_138697, NP_619642, Q5SY22, Q5SY24, Q7RTX1, Q8NGZ7, Q8TDJ7, Q8TDJ8, Q8TDJ9, Q8TDK0, T1R1, TR1, TS1R1_HUMAN
UCSC ID: uc001ant.3
RefSeq Accession: NM_138697
Protein: Q7RTX1 (aka TS1R1_HUMAN)
CCDS: CCDS81.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_138697.3
exon count: 6CDS single in 3' UTR: no RNA size: 2803
ORF size: 2526CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 5226.00frame shift in genome: no % Coverage: 99.71
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.