Human Gene TAS1R1 (uc001ant.3) Description and Page Index
Description: Homo sapiens taste receptor, type 1, member 1 (TAS1R1), transcript variant 2, mRNA. RefSeq Summary (NM_138697): The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]. Transcript (Including UTRs) Position: hg19 chr1:6,615,338-6,639,817 Size: 24,480 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr1:6,615,434-6,639,644 Size: 24,211 Coding Exon Count: 6
ID:TS1R1_HUMAN DESCRIPTION: RecName: Full=Taste receptor type 1 member 1; AltName: Full=G-protein coupled receptor 70; Flags: Precursor; FUNCTION: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. SUBUNIT: Forms heterodimers with TAS1R3. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily. SEQUENCE CAUTION: Sequence=AAL91359.1; Type=Erroneous initiation; Sequence=AAL91360.1; Type=Erroneous initiation; Sequence=AAL91361.1; Type=Erroneous initiation; Sequence=BAC05845.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=Protein Spotlight; Note=The taste experience - Issue 55 of February 2005; URL="http://web.expasy.org/spotlight/back_issues/sptlt055.shtml";
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): TAS1R1 CDC HuGE Published Literature: TAS1R1 Positive Disease Associations: Basophils Related Studies:
Basophils Yukinori Okada et al. PLoS genetics 2011, Identification of nine novel loci associated with white blood cell subtypes in a Japanese population., PLoS genetics.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00003 - 7 transmembrane sweet-taste receptor of 3 GCPR PF01094 - Receptor family ligand binding region PF07562 - Nine Cysteines Domain of family 3 GPCR PF13458 - Periplasmic binding protein
ModBase Predicted Comparative 3D Structure on Q7RTX1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.