Human Gene IL17B (uc003lqo.3) Description and Page Index
  Description: Homo sapiens interleukin 17B (IL17B), mRNA.
RefSeq Summary (NM_014443): The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015].
Transcript (Including UTRs)
   Position: hg19 chr5:148,753,830-148,758,838 Size: 5,009 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr5:148,753,932-148,758,788 Size: 4,857 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:148,753,830-148,758,838)mRNA (may differ from genome)Protein (180 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCHPRDLynxMGIneXtProt
OMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: IL17B_HUMAN
DESCRIPTION: RecName: Full=Interleukin-17B; Short=IL-17B; AltName: Full=Cytokine Zcyto7; AltName: Full=Interleukin-20; Short=IL-20; AltName: Full=Neuronal interleukin-17-related factor; Flags: Precursor;
FUNCTION: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.
SIMILARITY: Belongs to the IL-17 family.
WEB RESOURCE: Name=Wikipedia; Note=Interleukin-17 entry; URL="http://en.wikipedia.org/wiki/Interleukin_17";
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il17b/";

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): IL17B
CDC HuGE Published Literature: IL17B
Positive Disease Associations: Alzheimer Disease , Body Mass Index , Triglycerides
Related Studies:
  1. Alzheimer Disease
    , , . [PubMed 0]
  2. Body Mass Index
    , , . [PubMed 0]
  3. Triglycerides
    , , . [PubMed 0]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: IL17B
Diseases sorted by gene-association score: leiomyoma (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.58 RPKM in Nerve - Tibial
Total median expression: 44.25 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -18.0050-0.360 Picture PostScript Text
3' UTR -26.10102-0.256 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010345 - Interleukin-17
IPR020440 - Interleukin-17_chordata

Pfam Domains:
PF06083 - Interleukin-17

SCOP Domains:
57501 - Cystine-knot cytokines

ModBase Predicted Comparative 3D Structure on Q9UHF5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005125 cytokine activity

Biological Process:
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007267 cell-cell signaling
GO:0010469 regulation of receptor activity
GO:1900017 positive regulation of cytokine production involved in inflammatory response

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space


-  Descriptions from all associated GenBank mRNAs
  KJ893610 - Synthetic construct Homo sapiens clone ccsbBroadEn_03004 IL17B gene, encodes complete protein.
AF184969 - Homo sapiens cytokine-like protein ZCYTO7 (ZCYTO7) mRNA, complete cds.
AF152098 - Homo sapiens interleukin 17B mRNA, complete cds.
AY358931 - Homo sapiens clone DNA59294 IL17 B (UNQ516) mRNA, complete cds.
AF110385 - Homo sapiens interleukin-17 beta mRNA, complete cds.
AF212311 - Homo sapiens interleukin 20 (IL20) mRNA, complete cds.
AF218727 - Homo sapiens neuronal interleukin-17 related factor mRNA, complete cds.
BC113925 - Homo sapiens interleukin 17B, mRNA (cDNA clone MGC:138900 IMAGE:40084832), complete cds.
BC113946 - Homo sapiens interleukin 17B, mRNA (cDNA clone MGC:138901 IMAGE:40084836), complete cds.
JD099744 - Sequence 80768 from Patent EP1572962.
JD218235 - Sequence 199259 from Patent EP1572962.
AB590699 - Synthetic construct DNA, clone: pFN21AE1662, Homo sapiens IL17B gene for interleukin 17B, without stop codon, in Flexi system.
CR457192 - Homo sapiens full open reading frame cDNA clone RZPDo834G048D for gene IL17B, interleukin 17B; complete cds, incl. stopcodon.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04060 - Cytokine-cytokine receptor interaction

-  Other Names for This Gene
  Alternate Gene Symbols: IL17B_HUMAN, IL20, NIRF, NM_014443, NP_055258, Q14CE5, Q9UHF5, UNQ516/PRO1031, ZCYTO7
UCSC ID: uc003lqo.3
RefSeq Accession: NM_014443
Protein: Q9UHF5 (aka IL17B_HUMAN or I17B_HUMAN)
CCDS: CCDS4297.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_014443.2
exon count: 3CDS single in 3' UTR: no RNA size: 711
ORF size: 543CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1286.00frame shift in genome: no % Coverage: 97.75
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.