Human Gene IL17B (uc003lqo.3) Description and Page Index
Description: Homo sapiens interleukin 17B (IL17B), mRNA. RefSeq Summary (NM_014443): The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015]. Transcript (Including UTRs) Position: hg19 chr5:148,753,830-148,758,838 Size: 5,009 Total Exon Count: 3 Strand: - Coding Region Position: hg19 chr5:148,753,932-148,758,788 Size: 4,857 Coding Exon Count: 3
ID:IL17B_HUMAN DESCRIPTION: RecName: Full=Interleukin-17B; Short=IL-17B; AltName: Full=Cytokine Zcyto7; AltName: Full=Interleukin-20; Short=IL-20; AltName: Full=Neuronal interleukin-17-related factor; Flags: Precursor; FUNCTION: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary. SIMILARITY: Belongs to the IL-17 family. WEB RESOURCE: Name=Wikipedia; Note=Interleukin-17 entry; URL="http://en.wikipedia.org/wiki/Interleukin_17"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il17b/";
Genetic Association Studies of Complex Diseases and Disorders
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UHF5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.