Human Gene KANK4 (uc001dah.4) Description and Page Index
  Description: Homo sapiens KN motif and ankyrin repeat domains 4 (KANK4), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:62,701,837-62,785,083 Size: 83,247 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr1:62,703,949-62,747,236 Size: 43,288 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:62,701,837-62,785,083)mRNA (may differ from genome)Protein (995 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=KN motif and ankyrin repeat domain-containing protein 4; AltName: Full=Ankyrin repeat domain-containing protein 38;
FUNCTION: May be involved in the control of cytoskeleton formation by regulating actin polymerization.
TISSUE SPECIFICITY: Strongly expressed in colon, liver, lung, skeletal muscle and kidney.
SIMILARITY: Contains 5 ANK repeats.

-  MalaCards Disease Associations
  MalaCards Gene Search: KANK4
Diseases sorted by gene-association score: nephrotic syndrome, kank4-related* (100)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.05 RPKM in Nerve - Tibial
Total median expression: 29.42 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -220.00377-0.584 Picture PostScript Text
3' UTR -673.392112-0.319 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom
IPR021939 - KN_motif

Pfam Domains:
PF00023 - Ankyrin repeat
PF12075 - KN motif
PF12796 - Ankyrin repeats (3 copies)
PF13606 - Ankyrin repeat
PF13637 - Ankyrin repeats (many copies)
PF13857 - Ankyrin repeats (many copies)

SCOP Domains:
48403 - Ankyrin repeat

ModBase Predicted Comparative 3D Structure on Q5T7N3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0015630 microtubule cytoskeleton

-  Descriptions from all associated GenBank mRNAs
  AB284127 - Homo sapiens Kank4 mRNA for kidney ankyrin repeat-containing protein 4, complete cds.
BC060866 - Homo sapiens KN motif and ankyrin repeat domains 4, mRNA (cDNA clone MGC:71814 IMAGE:30344114), complete cds.
AK091941 - Homo sapiens cDNA FLJ34622 fis, clone KIDNE2014978, weakly similar to NG28.
AX747268 - Sequence 793 from Patent EP1308459.
JD125719 - Sequence 106743 from Patent EP1572962.
JD055244 - Sequence 36268 from Patent EP1572962.
JD306381 - Sequence 287405 from Patent EP1572962.
JD169729 - Sequence 150753 from Patent EP1572962.
JD529450 - Sequence 510474 from Patent EP1572962.
AK096259 - Homo sapiens cDNA FLJ38940 fis, clone NT2NE2015860, weakly similar to Erythroid ankyrin.
JD263434 - Sequence 244458 from Patent EP1572962.
JD270865 - Sequence 251889 from Patent EP1572962.
JD539003 - Sequence 520027 from Patent EP1572962.
BC033147 - Homo sapiens KN motif and ankyrin repeat domains 4, mRNA (cDNA clone IMAGE:4122850), with apparent retained intron.
AL832644 - Homo sapiens mRNA; cDNA DKFZp451K0518 (from clone DKFZp451K0518).
JD200815 - Sequence 181839 from Patent EP1572962.
JD470483 - Sequence 451507 from Patent EP1572962.
JD561221 - Sequence 542245 from Patent EP1572962.
JD409639 - Sequence 390663 from Patent EP1572962.
JD042702 - Sequence 23726 from Patent EP1572962.
JD290280 - Sequence 271304 from Patent EP1572962.
JD281215 - Sequence 262239 from Patent EP1572962.
BC041418 - Homo sapiens KN motif and ankyrin repeat domains 4, mRNA (cDNA clone IMAGE:3445545), partial cds.
AK127461 - Homo sapiens cDNA FLJ45553 fis, clone BRTHA2038345, highly similar to Ankyrin repeat domain-containing protein 38.
JD535092 - Sequence 516116 from Patent EP1572962.
JD301863 - Sequence 282887 from Patent EP1572962.
KJ900360 - Synthetic construct Homo sapiens clone ccsbBroadEn_09754 KANK4 gene, encodes complete protein.
JD210835 - Sequence 191859 from Patent EP1572962.
JD100740 - Sequence 81764 from Patent EP1572962.
JD477006 - Sequence 458030 from Patent EP1572962.
JD388733 - Sequence 369757 from Patent EP1572962.
JD071622 - Sequence 52646 from Patent EP1572962.
JD337802 - Sequence 318826 from Patent EP1572962.
JD383750 - Sequence 364774 from Patent EP1572962.
JD361288 - Sequence 342312 from Patent EP1572962.
JD394703 - Sequence 375727 from Patent EP1572962.
JD470220 - Sequence 451244 from Patent EP1572962.
JD222504 - Sequence 203528 from Patent EP1572962.
JD071592 - Sequence 52616 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ANKRD38, B1ALP7, KANK4_HUMAN, NM_181712, NP_859063, Q5T7N3, Q6P9A0, Q86T71, Q86VE6, Q8NAX3
UCSC ID: uc001dah.4
RefSeq Accession: NM_181712
Protein: Q5T7N3 (aka KANK4_HUMAN)

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_181712.4
exon count: 10CDS single in 3' UTR: no RNA size: 5477
ORF size: 2988CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 6162.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.