Human Gene SLC9C1 (uc003dyu.3) Description and Page Index
Description: Homo sapiens solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 (SLC9C1), mRNA. RefSeq Summary (NM_183061): SLC9A10 is a member of the sodium-hydrogen exchanger (NHE) family (see SLC9A1, MIM 107310) and is required for male fertility and sperm motility (Wang et al., 2003 [PubMed 14634667]).[supplied by OMIM, Apr 2009]. Transcript (Including UTRs) Position: hg19 chr3:111,859,752-112,013,074 Size: 153,323 Total Exon Count: 29 Strand: - Coding Region Position: hg19 chr3:111,860,119-112,005,638 Size: 145,520 Coding Exon Count: 28
ID:SL9C1_HUMAN DESCRIPTION: RecName: Full=Sodium/hydrogen exchanger 10; AltName: Full=Na(+)/H(+) exchanger 10; Short=NHE-10; AltName: Full=Solute carrier family 9 member 10; AltName: Full=Solute carrier family 9 member C1; AltName: Full=Sperm-specific Na(+)/H(+) exchanger; Short=sNHE; FUNCTION: Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity). SUBUNIT: Interacts with soluble adenylyl cyclase (sAC) (By similarity). SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane; Multi-pass membrane protein (By similarity). DOMAIN: The ion transport-like region is related to the membrane segments of voltage-gated ion channels. Its function is unknown (By similarity). SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. SIMILARITY: Contains 1 cyclic nucleotide-binding domain. SEQUENCE CAUTION: Sequence=DAA01462.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q4G0N8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.